With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.196811-66-2,tert-Butyl 4-carbamothioylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a suspension of 4-thiocarbamoyl-piperazine-1-carboxylic acid tert-butyl ester (13.3 mmol) in ethanol (60 mi) was added 4- (2-bromoacetyl)-benzoic acid (13.3 mmol) and 4- methylmorpholine (13.9 mmol). The reaction was heated at reflux for 2. 5 h. The reaction was concentrated in vacuo and the solid washed with water (200 ml) to yield the title compound as a white solid (3.9 g). 1H NMR (400MHz, CDCI3) 1.45 (9H, s), 3.58 (8H, m), 4.86 (1H, s), 6.95 (1H, s), 7.97 (2H, d, J 8 Hz), 8.1 (2H, d, J8Hz).
196811-66-2, The synthetic route of 196811-66-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MEDIVIR AB; WO2005/66180; (2005); A1;,
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