694499-26-8,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
To a solution of 4-[(4-methylpiperazin-l-yl)methyl]-3-(trifluoromethyl)aniline (0.7 equiv) in THF (4times) under nitrogen atmosphere was added 3-Iodo-4-methyl benzoyl chloride (1 equiv, prepared from the reaction of 3-iodo-4-methylbenzoic acid and SOCl2) in THF at room temperature for 30minutes followed by drop wise addition of (i-Pr)2EtN (2 equiv) and 4-DMAP (0.2 equiv). After stirring at ambient temperature for 120min, the reaction mixture was quenched with water, extracted with ethyl acetate. After drying over Na2S04, concentrated the ethyl acetate layer to provide the crude product. Acetone was added to this crude product and was converted to HC1 salt using IPA-HC1 (85% yield).
694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NATCO PHARMA LIMITED; KOMPELLA, Amala; GAMPA, Venugopala Krishna; GANGANAMONI, Srinivasulu; SIRIGIREDDY, Balakrishna Reddy; ADIBHATLA, Kali Satya Bhujanga Rao; NANNAPANENI, Venkaiah Chowdary; WO2015/186137; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics