With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
c) 4-r (4-MethoXvphenyl) amino1-N-r2-(4-methvlpiperazin-1-vl) ethyl1benz- amide; 97.3 mg (0.4 mmol) of the compound prepared in Example 6b are added to a suspension of 400 mg of commercial triphenylphosphine on polymer (3 mmol/g) in 1.1 ml of dichloromethane, followed by addition of 0.048 ml (0.48 mmol) of tri- chloroacetonitrile. After stirring for 3 hours at room temperature, the reaction medium is filtered and the filtrate is poured into a suspension of 329.7 mg of commercial N-methylmorpholine on polymer (3.64 mmol/g) and 62.9 mg (0. 4 mmol) of 2- (4-methylpiperazin-1-yl) ethylamine in 2.2 ml of THF. The new suspension is stirred for 16 hours at room temperature and then filtered. The fil- trate is concentrated under vacuum to give 110 mg of solid. (Yield: 74.6percent). NMR (CDCl3) : 1.8 (2H, m); 2.25 (3H, s); 2.4-2. 8 (8H, m); 3.5 (2H, m); 3.8 (3H, s); 5.8 (1 H, s); 6.8 (4H, m); 7.05 (2H, m); 7.5-7. 7 (3H, m).
934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK PATENT GMBH; WO2003/76406; (2003); A1;,
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