129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To 7-bromo-2-(chloromethyl)-5-cyclopropyl-6-methyl-oxazolo[4, 5-c]qui nol in-4-one (Intermediate 2) (150 mg, 0.41 mmol) and potassium phosphate tribasic (173 mg, 0.82 mmol) in dry (mol. sieves) and degassed DMF (5 mL) under N2 was added methyl 4-Boc- piperazine-2-carboxylate (199 mg, 0.82 mmol). The reaction mixture was heated to 80C under microwave irradiation for 1 h. On cooling H20 (20 mL) was added to the reaction mixture followed by EtOAc (30 mL) and the layers were separated. The organic layer was washed with H20 (3 x 20 mL) and the solvent was removed in vacuo. The crude reaction product was purified by flash silica chromatography using a gradient of 0-50% EtOAc in DCM as the eluent. The solvent was removed from fractions containing the desired product to give 1 -tert-butyl 3-methyl 4-[(7-bromo-5-cyclopropyl-6-methyl-4-oxo-oxazolo[4, 5- c]quinolin-2-yl)methyl]piperazine-1 ,3-dicarboxylate (132 mg, 56 % yield).LC-MS (Method F) 575.3/577.3 [M+H] RT 3.50 mm, 129799-08-2
The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; REDX PHARMA PLC; HUXLEY, Anthony; KIRK, Ralph; NOONAN, Gary; UOSIS-MARTIN, Mario; BARDELL-COX, Oliver; STOKES, Neil; (276 pag.)WO2017/46606; (2017); A1;,
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