109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4-bromobenzonitrile 12 (1.5 g, 8.24 mmol) in toluene, N-methylpiperazine (1.4mL, 12.36 mmol), sodium tert-butoxide(1.19 g, 12.36 mmol), Tris(dibenzylideneacetone)dipalladium(0) (0.023 g, 0.02mmol), and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) (0.036 g, 0.05mmol) were added. The reaction mixture was heated at 80 C for 16 hours andthen filtered on celite pad. The organic phase was evaporated under reducedpressure. The brown oil was purified by flash chromatography on silica gel(Eluent: CH2Cl2:MeOH 9:1). Compound 13 was obtained as a yellow oil (60%). 1H NMR (400 MHz,CDCl3): delta(ppm) 2.25(s, 3H); 2.46(t, J=8, 4H); 3.25-3.23(t, J=8, 4H);6.76(d, J=8, 2H); 7.39(d, J=8, 2H). Anal. Calcd. for C12H15N3:C, 71.61; H, 7.51; N, 20.88; found: C, 71.21; H, 7.21; N, 20.78
109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Radi, Marco; Bernardo, Vincenzo; Vignaroli, Giulia; Brai, Annalaura; Biava, Mariangela; Schenone, Silvia; Botta, Maurizio; Tetrahedron Letters; vol. 54; 38; (2013); p. 5204 – 5206;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics