21655-48-1, cis-2,6-Dimethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[7261 Step 1: Synthesis of (3R.55?)- 1 -benzyl-3 .5-dimethvlpiperazine [7271 (2S,6R)-2,6-dimethylpiperazine (1.000 g, 8.757 mmol) and K2C03(1.724 g, 13.136 mmol) were dissolved in acetonitrile (5OmL), and benzylbromide (1.092 mL, 9.195 mmol) was added thereto at 0 ¡ãC, and the mixture was stuffed at the same temperature for 1 hour and 30 minutes. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of sodium chloride, dried with anhydrous magnesium sulfate, and then concentrated under reduced pressure. The concentrate was purified by column chromatography (silicon dioxide; methanol/methylene chloride = 5 percent) and concentrated to afford the desired compound (1.170 g, 65.4 percent) as a yellow oil., 21655-48-1
The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHONG KUN DANG PHARMACEUTICAL CORP.; SONG, Hyeseung; LEE, Changgon; KWAK, Dalyong; LEE, Jaeyoung; BAE, Suyeal; KIM, Yuntae; BAE, Daekwon; HA, Nina; BAE, Miseon; KIM, Jihyun; WO2015/137750; (2015); A1;,
Piperazine – Wikipedia
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