59702-07-7, 1-Methylpiperazin-2-one is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of (8-((5-cyano-4-((2-methoxyethyl)amino)pyridin-2-yl)carbamoyl)-2-(dimethoxymethyl)-5,6 ,7 ,8-tetrahydro-1 ,8-naphthyridin-3-yl)methyl methanesu Ifonate (intermediate170, 368 mg, 0.657 mmol) in DCM (2.7 ml) at room temperature was added NEt3 (0.319 ml, 2.301mmol) followed by 1-methylpiperazin-2-one (120 mg, 1.052 mmol). The reaction mixture was stirred at room temperature for 2 h and partitioned between DCM and water. The water layer was extracted multiple times with DCM, the combined organic layers were dried using Na2504, filtered and evaporated. The crude product was purified by silica gel column chromatography usinggradient of MeOH (0-3percent) in DCM to yield the title compound as a white solid. (UPLC-MS 3) tR 0.87mm; ESl-MS 553.3 [M+H].1H NMR (600 MHz, CDCI3)5 13.75 (s, IH), 8.20 (s, IH), 7.64 (brs, IH),7.58 (s, I H), 5.56 (s, I H), 5.23 (d, I H), 4.06 ? 4.01 (m, 2H), 3.70 (br s, 2H), 3.63 (t, 2H), 3.503.42 (m, 8H), 3.40 (s, 3H), 3.31 (br s, 2H), 3.14 (br s, 2H), 2.96 (br s, 3H), 2.87 ?2.80 (m, 2H), 2.71(br s, 2H), 2.03 ? 1.96 (m, 2H)., 59702-07-7
59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; BUSCHMANN, Nicole; FAIRHURST, Robin Alec; FURET, Pascal; KNOePFEL, Thomas; LEBLANC, Catherine; MAH, Robert; NIMSGERN, Pierre; RIPOCHE, Sebastien; LIAO, Lv; XIONG, Jing; ZHAO, Xianglin; HAN, Bo; WANG, Can; WO2015/59668; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics