4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: r5-(4-lsopropyl-piperazin-1 -yl)-2-(4-methylsulfanyl-phenoxy)- benzyli-methyl-carbamic acid tert-butyl ester.; A mixture of [5-bromo-2-(4- methylsulfanyl-phenoxy)-benzyl]-methyl-carbamic acid tert-butyl ester (300 mg, 0.684 mmol) {prepared in an analogous fashion to Example 1 , Steps A-C}, isopropyl piperazine (132 mg, 1.02 mmol), XPHOS (39 mg, 0.082 mmol), Pd2(dba)3 (62.6 mg, 0.0684 mmol), and t-BuONa (98.0 mg, 1.02 mmol) in toluene was heated in a sealed tube overnight at 120 0C. After cooling to rt, the mixture was filtered through diatomaceous earth and the filtrate was concentrated. Purification by FCC gave the desired product (180 mg, 54percent). MS (ESI): mass calcd. for C27H39N3O3S, 485.27; m/z found, 486.4 [M+H]+. 1H NMR (CDCI3): 7.22 (d, J = 8.5, 2H), 6.86-6.83 (m, 1 H), 6.83-6.80 (m, 4H), 4.42- 4.35 (m, 2H), 3.19-3.16 (m, 4H), 2.87-2.83 (m, 2H), 2.80-2.75 (m, 1 H), 2.75- 2.71 (m, 1 H), 2.71-2.67 (m, 4H), 2.44 (s, 3H), 1.48-1.40 (m, 9H), 1.10 (d, J = 6.5, 6H).
4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; JANSSEN PHARMACEUTICA N.V.; WO2008/2820; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics