New learning discoveries about 59702-07-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59702-07-7,1-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.

Example 1786-(3-fluorophenyl)-N-{(1S,3R)-3-[(4-methyl-3-oxopiperazin-1 -yl)carbonyl] cyclopenty^nicotinamide To a solution of (1 R, 3S)-3-({[6-(3-fluorophenyl)pyridine-3-yl]carbonyl}amino) cyclyopentanecarboxylic acid (Example 1 1 b, 49.3 mg, 0.15 mmol) and triethylamine (68.2 mg, 0.675 mmol) in dimethylformamide (1.3 mL) was added HBTU (65.2 mg, 0.172 mmol) and the solution was stirred at room temperature for 1 hour. 1-Methylpiperazin-2-one (29.4 mg, 0.195 mmol) was added and the solution was stirred at room temperature overnight. The dimethylformamide was removed by evapouration in vacuo and the residue was partitioned between water (7 mL) and ethyl acetate (7 ml_). The organic layer was separated and evaporated to give a red-brown gum which was purified by HPLC Method (B) to give 23.2 mg of the title compound (LCMS Method (A), RT 2.83 min, 100percent area ES m/z [M+] 424.19).

59702-07-7, 59702-07-7 1-Methylpiperazin-2-one 4399042, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; PFIZER LIMITED; WO2009/153720; (2009); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics