With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1030377-21-9,(S)-1-Boc-2-(Hydroxymethyl)piperazine,as a common compound, the synthetic route is as follows.
A mixture of (S)-tert-butyl 2-(hydroxymethyl)piperazine-l -carboxylate (602.7 mg, 2.79 mmol) and (S)-2-methoxyoxirane (308.9 mg, 3.4 mmol) in ethanol (10 mL) was heated at 120 C for 30 min using microwave. The mixture was concentrated to dryness. The residue was purified with flash column chromatography on silica gel using 1 -10% methanol in dichloromethane to afford a oil as the product (794.6 mg) in 94% yield. NMR (500 MHz, Chloroform-*/) delta 4.11 (br, 1H), 3.93 – 3.80 (m, 2H), 3.41 (dd, J = 9.7, 3.7 Hz, 1H), 3.36 (s, 3H), 3.33 (dd, J = 9.7, 6.0 Hz, lH), 3.25 (br, 2H), 3.06 (d, J = 1 1.6 Hz, 1H), 2.89 (br, 2H), 2.79 (d, J = 1 1.2 Hz, 1H), 2.47 (dd, J = 12.7, 9.1 Hz, 1H), 2.49 – 2.33 (m, 1 H), 2.30 – 2.21 (m, 2H), 1.43 (s, 9H). MS for C,4H28N205: 305.2 (MH+).
1030377-21-9, As the paragraph descriping shows that 1030377-21-9 is playing an increasingly important role.
Reference£º
Patent; NEKTAR THERAPEUTICS (INDIA) PVT. LTD.; NEKTAR THERAPEUTICS; SHARMA, PANKAJ; KHATRI, VIJAY KUMAR; GU, XUYUAN; SONG, YUAN; SHEN, MICHAEL LIXIN; SAUTHIER, JENNIFER RIGGS; ANAND, NEEL K.; KOZLOWSKI, ANTONI; ODINECS, ALEKSANDRS; RILEY, TIMOTHY A.; REN, ZHONGXU; MU. YONGQI; SHEN, XIAOMING; YUAN. XUEJUN; AURRECOECHEA, NATALIA; O’MAHONY, DONOGH JOHN ROGER; WO2015/92819; (2015); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics