With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
A solution of 1- (piperazin-1-yl) ethan-1-one (3.59 g, 28 mmol) and potassium carbonate (3.88 g, 28 mmol) were added to N, N-dimethylformamide (40 mL)Then 4-fluoro-2-methoxy-1-nitrobenzene (4.09 g, 23 mmol) was added to the suspension and stirred at 80 C overnight. The mixture was poured into water, The solid precipitate was filtered off. The resulting solid was dried in vacuo at 50 C, A yellow solid (3.5 g, yield: 45%)
13889-98-0, The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Fudan University; Shanghai Institute of Materia Medica, Chinese Academy of Sciences; Li, Yingxia; Ding, Jian; Xiao, Qiang; Geng, Meiyu; Liu, Jian; Xie, Hua; (24 pag.)CN106608868; (2017); A;,
Piperazine – Wikipedia
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