With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.694499-26-8,4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
Example 8: 6-[[2-(Cyclopropylcarbonyl)amino-pyridin-4-yl]oxy]-naphthalene-1-carboxylic acid [4-[(4-methyl-1-piperazinyl)methyl]-3-trifluoromethyl-phenyl]amide; Under an argon atmosphere, a stirred solution of 4-[(4-methyl-1-piperazinyl)methyl]-3- (trifluoromethyl)benzenamine (0.131 g, 0.48 mmol) in dry toluene (5 ml_) is treated with a solution Of AIMe3 (0.6 mL of 2 M in toluene; 1.1 mmol) at 18C. After 30 min, a solution of 3- [[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]oxy]-1-naphthalenecarboxylic acid, methyl ester (0.174 g, 0.48 mmol) in toluene (5 ml_) is added and the mixture is heated for 2 h at 85- 95C. The cooled mixture is then added to a saturated aqueous solution of NH4CI, stirred for 30 min and extracted with ethyl acetate. The combined extracts are washed (brine), dried (Na2SO4) and solvent is evaporated off under reduced pressure to give a residue, which is purified by column chromatography (SiO2; dichloromethane/methanol/aqueous
694499-26-8 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 46838908, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NOVARTIS AG; WO2008/125691; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics