With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24860-46-6,2-(2-Oxopiperazin-1-yl)acetic acid,as a common compound, the synthetic route is as follows.
EXAMPLE C. PREPARATION OF 2-OXO-1,4-PIPERAZINEDIACETIC ACID; LACTAM OF ETHYLENEDIAMINETRIACETIC ACID. Approximately 40.8 g of 2-oxo-l-piperazineacetic acid, prepared by the procedure of Example B, and 70 g of deionized water were added to a beaker and stirred for several hours with a magnetic stirrer bar. The contents were filtered using a medium glass frit funnel and vacuum. The filtrate and 20.0 g of bromoacetic acid were added to a beaker and stirred till all the bromoacetic acid had dissolved. The pH was adjusted to approximately 7 with 25% sodium hydroxide solution. The temperature was maintained at less than 25 C. during the caustic addition by cooling in an ice-water bath. The ice-water bath was removed and the mix allowed to stir for approximately 4-5 hours at approximately 35 C. while maintaining the pH at about 7 by the periodic addition of 25% sodium hydroxide solution. The reaction mix was allowed to stand for several hours and then concentrated (in vacuo) to a weight of approximately 90-100 g and filtered using a medium glass frit funnel and vacuum. Volatiles were removed (in vacuo) from the filtrate at a temperature of 55-60 C. and the material dried in a vacuum oven at 55-60 C. for several hours. The lactam of ethylenediaminetriacetic acid was confirmed by proton and carbon NMR., 24860-46-6
The synthetic route of 24860-46-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; The Dow Chemical Company; US5342604; (1994); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics