With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
Description 146(S)-tert-butyl 3-methylpiperazine-1-carboxylate (1)146)NHBocTo a solution of (S)-2-methylpiperazine (500 mg) in DCM (5 mL) was added Et3N (1010 mg) and(Boc)20 (1198 mg) in DCM (3 mL) dropwise. The mixture was stirred at 0C for 2 hours. DCM(10 mL), water (5 mL) and 30% NaHSO4 (10 mL) aqueous solution were added to the reactionmixture. The resulted mixture was stirred for 10 mm, and to the aqueous layer was added saturatedNa2CO3 solution until pH = 8, extracted with isopropyl alcohol: chlorofonn1: 3 (5 x20 mL). The combined organic layer was washed with brine (5 mL), dried over Na2SO4, filtered and concentrated to afford the title compound (562 mg) as pale yellow oil, MS (ESI): C10H20N202 requires 200; found 201 [M+H]., 74879-18-8
The synthetic route of 74879-18-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
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