With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.
To a solution of (E)-methyl l-acetyl-3-(ethoxy(phenyl)methylene)-2-oxo- 2,3-dihydro-lH-pyrrolo[3,2-c]pyridine-6-carboxylate (40 mg, 0.109 mmol) in DMF (0.2 mL) was added N-(4-aminophenyl)-N-methyl-2-(4-methylpiperazin-l-yl)acetamide (28 mg, 0.109 mmol) at room temperature, and the reaction mixture was stirred at 110 C for 2h. The reaction mixture was cooled to RT, piperidine (0.2 mL) was added and stirred for 10 minutes at room temperature. The solvent was evaporated and the resulting residue was purified by silica gel column chromatography using 5% CH3OH in dichloromethane as eluent to afford (Z)-methyl 3- (((4-(N-methyl-2-(4-methylpiperazin-l-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo- 2,3-dihydro-lH-pyrrolo[3,2-c]pyridine-6-carboxylate as yellow solid. MS (ES+): m/z 541.3 (MH+)., 262368-30-9
The synthetic route of 262368-30-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ANGION BIOMEDICA CORP.; PANICKER, Bijoy; MISHRA, Rama, K.; JUNG, Dawoon; OEHLEN, Lambertus, J.W.M.; LIM, Dong, Sung; WO2013/112959; (2013); A1;,
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