With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Compound 9 (10g, 82.6mmol) placed in 500mL single-port flask, 200mLDMSO. At room temperature was added (2R, 6S) -2,6-dimethylpiperazine (14g, 124mmol) and K2CO3 (28.5g, 206.5mmol), and mix well. Then heated to 130 , reaction 8h. After completion of the reaction was poured into 1L of water. (150mL * 3) and extracted three times with ethyl acetate. The organic phase was washed with 100mL saturated brine, dried over anhydrous sodium sulfate, the solvent spin dried to give a yellowish solid 15g, yield 85%.
21655-48-1, The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ShangHai HaiHe Pharmaceutical Co., Ltd.; Shanghai Institute of Materia Medica Chinese Academy of Sciences; Geng, Meiyu; Liu, Lei; Jiang, Lei; Huang, Min; Chua, Chuantao; Ai, Jing; Wang, Lei; Cao, Jianhua; Ding, Jian; (58 pag.)CN105524048; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics