Downstream synthetic route of 5271-27-2

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.,5271-27-2

(S)-1 -methyl-3-phenylpiperazine.(+)Anicyphos salt 100 g of (R,S)-1-methyl-3-phenylpiperazine (1 ) (567 mmole) and 154.5 g of (+)- Anicyphos (571 mmole) were dissolved in 250 ml of water by heating the mixture to reflux. After cooling down to room temperature a seed crystal was added. After two hours, the white crystals formed were collected by filtration and dried in a vacuum oven at 40 0C for 21 hours. This provided 121 g (48 percent) with an ee of 85.5percent. The crystals were dissolved in water (119 ml) at reflux temperature. After cooling down the crystallization started. After one hour the crystals were collected by filtration and dried in a vacuum oven at 40 0C. The yield of the crystals of (S)-1-methyl-3- phenylpiperazine.Anicyphos salt was 105.8 g (42 percent, ee 99.0percent). The ee was determined by HPLC analysis: Chiralcel OD 250*4.6mmlD (Daicel), 5 percent iso-propylalcohol in hexane, flow rate 1.0 ml.min”1, UV-detector, column temperature 40 0C, retention times 5.6 min, 6.3 min.

As the paragraph descriping shows that 5271-27-2 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; WO2008/125578; (2008); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics