13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 4. 1-{4-[4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(2-chloro-4-methoxyphenoxy)pyrimidin-2-yl]-piperazin-1-yl}ethanone To a solution of 6-[(1H-benzoimidazol-2-ylmethyl)-amino]-4-(2-chloro-4-methoxyphenoxy)-2-(methylsulfonyl)pyrimidine (300 mg, 0.65 mmoles), 1-acetyl piperazine (125 mg, 0.98 mmoles), DMF (4 mL) in a 10 mL microwave vial was added TEA (0.66 mL, 0.65 mmoles). The solution was degassed with N2 for 10 min before being capped and heated in a microwave reactor for 10 min at 120 C. Once complete, the reaction was diluted with 1 M NaOH (10 mL) and EtOAc (20 mL). The EtOAc layer was separated, dried over MgSO4, filtered, and concentrated under reduced pressure. The crude product was submitted for flash chromatography purification. the title compound was obtained in (298 mg, 90% yield). LCMS: 508 (M+H)+. (M+1=508.09, Retention time=2.52; 5-99% CH3 CN/H2 0 gradient with 0.01% TFA).
13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference£º
Patent; TRIUS THERAPEUTICS; US2008/194545; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics