Month: February 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of 2-(3-bromopropyl) isoindoline-1,3-dione (1.0 g, 1 mmol) in N,N-dimethyl formamide DMF(5 mL), N-phenyl piperazine derivatives (1 mmol) andK2CO3 (1.1 g, 3 mmol) were added at room temperature.The reaction mixture was stirred at room temperature for 24h. The resulting solution was poured into ice cold water,which was then extracted with ethyl acetate. Ethyl acetatewas separated, dried over Na2SO4, and concentrated undervacuum to afford corresponding compounds 8a-g.

30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.

Reference£º
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Janardhan, Sridhara; Jain, Nishant; Bantu, Rajashaker; Nagarapu, Lingaiah; Medicinal Chemistry Research; vol. 25; 9; (2016); p. 2070 – 2081;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 2: Preparation of 1-(4-(3-methoxy-4-nitrophenyl)piperazin-1-yl)ethanone The compound obtained in Step 1 above (300 mg), N-acetylpiperazine (300 mg), and potassium carbonate (500 mg) were dissolved in dimethylformamide (3 mL) and reacted at 80C overnight. The dimethylformamide of the reaction mixture was removed under reduced pressure, and added with water to form a solid. The solid was filtered to obtain a target compound as a yellow solid. 1H-NMR(300 MHz, CDCl3) delta 8.00(d, J = 9.1 Hz, 1H), 6.42(d, J = 9.1 Hz, 1H), 6.32(s, 1H), 3.96(s, 3H), 3.80-3.79(m, 2H), 3.67-3.65(m, 2H), 3.47-3.40(m, 4H), 2.15(s, 3H); Mass (M+H+) calcd for C13H17N3O4 279.12, found 279.20, 13889-98-0

13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Korea Research Institute of Chemical Technology; LEE, Kwangho; KIM, Hyoung Rae; PARK, Chi Hoon; LEE, Chong Ock; LEE, Jong Kook; JUNG, Hee Jung; CHO, Sung Yun; CHAE, Chong Hak; CHOI, Sang Un; HA, Jae Du; EP2883875; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

50606-32-1, Butyl piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

50606-32-1, PREPARATION 8: Preparation of piperazine-1-carboxylic acid methylamide 11 g (59 mmol) of N-butyloxycarbonylpiperazine was dissolved in 250 ml of anhydrous tetrahydrofuran, and then 20.6 ml (118 mmol) of N,N-diisopropylethylamine and 13.1 g (64.9 mmol) of 4-nitrophenylchloroformate were added thereto, followed by stirring under reflux for 1 hour. 177 ml of methylamine (2 M tetrahydrofuran solution) was added to the reaction, followed by stirring under reflux for 30 minutes. After completion of the reaction, the reaction solution was concentrated, after addition of 100 ml of water, and then extracted twice with 100 ml of dichloromethane. 30 ml of 4 N hydrochloric acid/l,4-dioxane solution was added thereto, followed by stirring for 5 hours at room temperature. A solid, which was produced from completion of the reaction, was filtered off and dried to obtain 9.53 g (53 mmol, yield of 90%) of the title compound as hydrochloride salt.1H NMR (DMSOd6, ppm); delta 9.28 (IH, bs), 7.94 (IH, bs), 3.52 (4H, m), 3.01 (4H, m), 2.57 (3H, s)FAB MS(m/e) = 144 [M+l]

The synthetic route of 50606-32-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LG LIFE SCIENCES, LTD.; WO2007/58482; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

639068-43-2, tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of compound 13a-b, 17a-b (1.0 mmol) inCH3CN (20 mL) were added N-Boc-piperazine (180.9 mg,0.9 mmol), K2CO3 (205.9 mg, 1.5 mmol), KI (166.0 mg, 1.0 mmol)and 18-crown-6 (26.4 mg, 0.1 mmol) at room temperature. Themixture was stirred overnight at 80 C and filtered. The filtrate wasdiluted by DCM and washed by brine. The organic layer was concentrated for next step. To a stirred solution of the abovecompounds in DCM (20 mL) was added TFA (3 mL) at room temperature.The mixture was stirred for 3e4 h and concentrated toafford the crude products 15a-o and 19a-f in a yield of 35%e42%. Toa stirred solution of above crudes in anhydrous MeOH (10 mL) wasadded BTZ core compound 11 (403.2 mg, 1.0 mmol) and Et3N(0.2 mL, 1.5 mmolj) at room temperature. The mixture was stirredfor 1e3 h at 40 C and concentrated. The residue was purified bysilica gel column (DCM: MeOH 20: 1) to give 1a-f and 2a-e (25%e41% for two steps)., 639068-43-2

As the paragraph descriping shows that 639068-43-2 is playing an increasingly important role.

Reference£º
Article; Wang, Apeng; Lv, Kai; Tao, Zeyu; Gu, Jian; Fu, Lei; Liu, Mingliang; Wan, Baojie; Franzblau, Scott G.; Ma, Chao; Ma, Xican; Han, Bing; Wang, Aoyu; Xu, Shijie; Lu, Yu; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.262368-30-9,N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide,as a common compound, the synthetic route is as follows.

To a solution of methyl 2-oxo-2,3-dihydro-lH-pyrrolo[2,3-b]pyridine-6- carboxylate (1 g, 5.20 mmol) in AC2O (10 mL) was added triethyl orthobenzoate (3.40 g, 15.59 mmol) at RT and the mixture was heated to reflux for 3 h. The reaction mixture was evaporated and the resultant residue was purified by silica gel column chromatography using 5% CH3OH in dichloromethane as eluent to afford (E)-methyl l-acetyl-3-(ethoxy(phenyl)methylene)-2-oxo- 2,3-dihydro-lH-pyrrolo[2,3-b]pyridine-6-carboxylate as an orange solid. XH NMR (CDCI3, 500 MHz): delta 8.25 (d, J = 12.1 Hz, 1 H), 8.04 (d, J = 12.1 Hz, 1H), 7.53-7.60 (m, 3H), 7.38-7.45 (m, 2H), 4.40 (q, J = 7.1 Hz, 2H), 3.99 (s, 3H), 2.63 (s, 3H), 1.42 (t, J = 7.1 Hz, 3H)., 262368-30-9

262368-30-9 N-(4-Aminophenyl)-N-methyl-2-(4-methylpiperazin-1-yl)acetamide 21927707, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; ANGION BIOMEDICA CORP.; PANICKER, Bijoy; MISHRA, Rama, K.; JUNG, Dawoon; OEHLEN, Lambertus, J.W.M.; LIM, Dong, Sung; WO2013/112959; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.

Tert-butyl N – [(6-bromohexylamino) – (tert-butoxycarbonylamino) methylene] carbamate (4.23 g) was dissolved in N, N- dimethylformamide (21 mL). To this was added benzylpiperazine-1-carboxylate (2.55 g) and potassium carbonate (1.66 g) sequentially at room temperature. Thereafter, the mixture was stirred at 50 ¡ã C. overnight. It was cooled to room temperature. The resulting solution was poured into water and extracted with ethyl acetate. The combined organic layer was dried over anhydrous magnesium sulfate. It was then filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to give the title compound (5.04 g, yield 90percent).

31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.

Reference£º
Patent; NIPPON SODA COMPANY LIMITED; IHORI, YOICHI; INOUE, SHUJI; SHIBAYAMA, KOTARO; KANG, CHANG-KYUNG; SHIINOKI, YASUYUKI; NISHIMURA, SATOSHI; (65 pag.)JP2016/222654; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

7-Bromo-1H-indole-2-carboxylic acid (1) (2.4 g, 10 mmol), 4-((4-methylpiperazin-1-)methyl)-3-(trifluoromethyl)aniline(2.73g, 10mmol) and 2-(7-oxobenzotriazole)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (HATU)(3.8 g, 10 mmol) dissolved in N,N-dimethylformamide,Diethylisopropylamine (1.65 mL, 10 mmol) was added.Stir until the reaction is complete, extract with ethyl acetate and water,The organic phase was concentrated and subjected to column chromatography to give 3.5 g of product, yield 70%., 694499-26-8

The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Seth Ming Qiang Pharmaceutical Technology Co., Ltd.; Zhang Qiang; Zhang Hongbo; Zhou Likai; Feng Shouye; Yang Hailong; Wang Zhongxiang; (54 pag.)CN109988151; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The reaction of1-bromo-4-nitrobenzene (0.20 g, 1.0 mmol), 1-(piperazin-1-yl)ethan-1-one (0.190 g,1.5 mmol), copper powder (0.0064 g, 0.1 mmol), MI (0.036 g, 0.2 mmol), Cs2CO35(0.720 g, 2.2 mmol), TBAHS (0.068 g, 0.2 mmol) produced 0.238 g (96%) of1-(4-(4-nitrophenyl)piperazin-1-yl)ethan-1-one as a yellow solid., 13889-98-0

The synthetic route of 13889-98-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zhou, Qifan; Du, Fangyu; Chen, Yuanguang; Fu, Yang; Chen, Guoliang; Tetrahedron Letters; vol. 60; 29; (2019); p. 1938 – 1941;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 2 – ((lH-pyrrolo [2,3-b] pyridin-5-yl) oxy) -4- (4 – ((4′-chloro-5,5-dimethyl- 2-yl) piperazin-1-yl) benzoic acid (160 mg, 0.28 mmol, 1.05 eq) and 6- (2-nitro 4-sulfamoylphenoxy-2-azaspiro [3.3] heptane-2-carboxylate (110 mg, 0.27 mmol, 1.0 eq) was added to DCM (10 mL) followed by EDCI (80 mg , 0.42 mmol, 1.57 eq) and 4-DMAP (40 mg, 0.33 mmol, 1.23 eq)Room temperature reaction for 16 h. After the reaction, the color becomes darker and becomes dark yellow. TLC point plate analysis, in the middle of a new two raw materials, sulfonamide raw materials there is a little bit. The reaction was stopped and the reaction was poured into water (40 mL) and extracted with DCM (15 mL x 3). The organic phase was dried over anhydrous sodium sulfate, dried over the column, and the column was passed through a column of EA / EtOH (v / v) = 20/1 to give 200 mg of a white solid product. Yield 77.07%.

1235865-77-6, 1235865-77-6 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 66713100, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Sunshine Lake Pharma Co.,Ltd.; Kou, Yuhui; Hu, Bolin; Jiang, Haigang; Ye, Jiuyong; Liu, Zhiqiang; Xie, Hongming; Zhang, Yingjun; (42 pag.)CN106565706; (2017); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step C: tert-butyl (38)-4-[2-(3-cyano-4-methoxy-2-methylphenyl)-2-oxoethyli-3-(hydroxymethyl)piperazine-1-carboxylate: To a solution of the 3-(bromoacetyl)-6-methoxy-2-methylbenzonitrile (2.25 g, 8.40 mmol) in THF was added tert-butyl (38)-3- (hydroxymethyl)piperazine-1-carboxylate (2.18 g, 10.8 mmol) and Hunig?s Base (2.93 mL, 16.8 mmol). The reaction was allowed to stir at RT for 16 hours. TLC showed good reaction at that point. The crude reaction was adsorbed onto silica gel, and purified by silica gel flash chromatography to afford the title compound., 314741-40-7

As the paragraph descriping shows that 314741-40-7 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics