Month: February 2021

196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

All of the alpha-bromoketone above and 4-thionocarbonylpiperazine-1-carboxylic acid tert- butyl ester {J. Med. Chem., 1998, 5037-5054, 917 mg, 3.73 mmol) were refluxed in 36 ml_ THF at 70 C for 2 h, under N2. The precipitate was filtered and the filtrate evaporated to give yellow solids. Flash column chromatography (silica, 5/1 petroleum ether – EtOAc) gave 624 mg of light yellow solids. Chromatography of the precicpitate (silica, 2/1 petroleum ether – EtOAc) gave 32 mg more of compound. Total yield is 44%.1 H NMR (CDCI3) delta ppm: 1.46 (s, 9H), 2.43 (s, 3H), 3.42, (m, 4H), 3.54 (m, 4H), 3.90 (s, 3H), 7.68 and 8.04 (ABq, 4H)., 196811-66-2

As the paragraph descriping shows that 196811-66-2 is playing an increasingly important role.

Reference£º
Patent; MEDIVIR AB; WO2008/114054; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 1 15Ctert-Butyl 4-(4-(9-(4-fluorophenyl)-3-oxo-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.

Reference£º
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel; WO2011/130661; (2011); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

3-nitro-4-(((tetrahydro-2H-pyran-4-yl)methyl)amino )benzenesulfonamide ( 4.73 g) wasdissolved m dichloromethane (124.8 mL) at 34C. 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (3.66 g) and 4-Dimethylaminopyridine(3.33 g) was added to the above solution and stirred for 10 minutes at 35C. A mixture of2-( ( 1H -pyrrolo [2,3-b ]pyridin-5-yl)oxy)-4-( 4-( ( 4′-chloro-5,5-dimethy 1-3,4,5 ,6-tetrahydro[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid (7.8 g), triethylamine (3.8 g) indichloromethane (70.2 mL) was stirred for 15 minutes at 35C and it was added dropwise to the above mixture in 15 minutes at the same temperature. The reaction mixturewas stirred for 23 hours at 31 oc and then evaporated the solvent from the reactionmixture to obtain residue. This residue was dissolved in ethyl acetate (80 mL) and washedthe solution with 10% acetic acid (2×80 mL), saturated aqueous sodium bicarbonatesolution (2×80 mL) and then with brine solution (2×80 mL). The separated organic layerwas dried over sodium sulfate and evaporated the solvent completely. The crude productwas combined with acetonitrile (112 mL) and stirred for 2 hour at 34C and filtered thesolid. The solid was dissolved in acetonitrile (60 mL) at 70C and stirred for 1 hour at thesame temperature. The solution was cooled and filtered the solid to obtain titlecompound. Yield: 4.5 g; Purity by HPLC: 99.65%, 1235865-77-6

1235865-77-6 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid 66713100, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; JURUPULA, Ramprasad; BAIG, Mohammed Azeezulla; CHAKKA, Ramesh; THIPPARABOINA, Rajesh; PEDDY, Vishweshwar; RAO, Pallavi; ORUGANTI, Srinivas; DAHANUKAR, Vilas Hareshwar; (88 pag.)WO2017/212431; (2017); A1;,
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Piperazines – an overview | ScienceDirect Topics

162046-66-4, 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a i-dram vial WaS added 4-(4-(lert-butoxvcarbonvi)piperazin-i-vi)henzoic acid (345 mg, 1127 mrnoi), THF (5 rnL), HATU (514mg, 1.352 mmol) and EtsN (0785 mL,5.63 rnrnol). The reaction was stirred at rt for 10 mm and then Intermediate 4 (450 mg,1.127 mmol) was added and the reaction was continued for 4 hr. The reaction was partitioned between EtOAc (20 ml) and water (15 ml). The organic layer was separated, washed with brine (15 ml). dried over MgSO4, filtered and concentrated. The residue was purified using 1SCO system (0-100% EtOAcLElex gradient, then 0-20%MeOH/CH2CI2 gradient) to give tert-but I 4-(4-(2-(3-methoxy-4-(1H-pyrazoi-4- yi)phenyi)- 1 -oxo-2,S-diazaspiro[4. 51 decane-8-carbonyi)phenyi)piperazine-1 -carboxylate (500 mg, 0.8 13 mrnol, 72.2 % yield) as a light beige solid. 1J4 NMR (500MHz, DMSOd6) oe 809 (hr. s.. 1FI). 793 (hr. s., IH),764 – 7.57 (m, 21:1), 7.31 (d. J:::55 Hz, 2H), 7.15 (dd, J=8.4, 2.1 Hz, 1H), 6.98 (d. J=8,8 Hz, 2H), 3.92 – 383 (m. 5H), 352 – 3.42 (m, 4H),3.28 (s, 414), 3.22 – 319 (m, 4H), 2.15 (t, J=6.9 Hz, 2H), 1.78 – 1.67 (in, 2H), 1.57 (d, .J::129 Hz, 2H). 143 (s, 91-1): MS (ESI) in/z: 615.1 (M+H)., 162046-66-4

162046-66-4 4-(4-(tert-Butoxycarbonyl)piperazin-1-yl)benzoic acid 2795508, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; ZHU, Yeheng; DEWNANI, Sunita, V.; EWING, William, R.; (265 pag.)WO2019/89868; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21043-40-3,1-Cyclopentylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 2 g (14 mmol) 6-chloronicotinonitrile (commercially available) 2.45 g (16 mmol) N-cyclopentylpiperazine (commercially available) and 1.86 g (14 mmol) N,N-diisopropylethylamine in 5 ml water and 15 ml DMF was heated to 90 C. for 24 h. After addition of 250 ml 1M NaHCO3 aq. solution the mixture was extracted three times with 250 ml ethyl acetate each. The combined organic phases were washed twice with 150 ml brine each, dried and evaporated to dryness. Recrystallization from ethyl acetate yielded a first batch of 2.83 g of white crystals. An additional batch was yielded from the filtrate and in total 3.14 g (85%)n of the title compound was obtained as white crystals. (m/e): 257.1 (MH+; 100%).

21043-40-3, As the paragraph descriping shows that 21043-40-3 is playing an increasingly important role.

Reference£º
Patent; Nettekoven, Matthias Heinrich; Roche, Olivier; Rodriguez-Sarmiento, Rosa Maria; US2006/122187; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 30 2,4-dichloro-3-nitroquinoline (6.17 gm, 2.54¡Á10?2 moles) in 31 tetrahydrofuran (100 mL) was stirred as 32 diisopropylethylamine (3.62 gm, 4.88 mL, 2.8¡Á10?2 moles) and 33 N-methyl-N?-(2-aminoethyl)piperazine (4.0 gm, 2.8¡Á10?2 moles) were added. This solution was stirred at room temperature overnight. The THF was removed under reduced pressure and the remaining material was partitioned between methylene chloride (200 mL) and water (200 mL). The aqueous was extracted a second time with 34 methylene chloride (100 mL). After being dried over magnesium sulfate, the combined extracts were filtered and the solvent was removed under reduced pressure. The remaining yellow oil was stirred with 35 diethyl ether (50 mL) and this was cooled on ice causing the product to crystallize. The solid yellow product was isolated by filtration, washed with ether and dried. The yield was 3.6 gm (40.5percent)., 934-98-5

As the paragraph descriping shows that 934-98-5 is playing an increasingly important role.

Reference£º
Patent; JANUS BIOTHERAPEUTICS, INC.; Lipford, Grayson B.; Zepp, Charles M.; (72 pag.)US9873694; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

393781-71-0, 1-Boc-2-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 16A tert-butyl (2R)-2-ethyl-4-[(6-{[5-(trifluoromethyl)pyridin-2-yl]oxy}quinolin-2-yl)carbonyl]piperazine-1-carboxylate. The product from Example 1D (200 mg, 0.59 mmol) was subjected to the conditions described in Example 11, substituting (R)-tert-butyl 2-ethylpiperazine-1-carboxylate for 4-(piperidin-4-yl)morpholine to give the titled compound (238 mg, 67.5%)., 393781-71-0

The synthetic route of 393781-71-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AbbVie Inc.; Bogdan, Andrew; Cowart, Marlon D.; DeGoey, David A.; Jinkerson, Tammie K.; Koenig, John R.; Kort, Michael E.; Liu, Bo; Matulenko, Mark A.; Nelson, Derek W.; Patel, Meena V.; Peltier, Hillary; Scanio, Marc J.; Wakefield, Brian D.; US2015/218102; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-15-1, Methyl 1-Boc-piperazine-2-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of (2-isopropylphenyl)[2-nitro-4-E-(carboxyethenyl)phenyl]sulfide (prepared according to the procedures of Example 32), the amine from Example 71A (1.0 eq), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (1.0 eq), and diisopropylethylamine (2.0 eq) in DMF was stirred at ambient temperature for 4 hr.ethyl acetate was added, and the mixture was washed sequentially with 1N HCl, aq. NaHCO3, and brine.The resultant yellow solid was treated with 1:1 TFA/dichloromethane at ambient temperature to give the title compound as a yellow solid. 1HNMR (DMSO-d6, 300 MHz) delta 1.15 (d, J=6.6 Hz, 6H); 2.52-3.16 (br m, 4H); 3.25-3.47 (m, 1H); 3.60-3.65 (br d, 3H); 3.60, 3.66 (br s, br s, 3H); 6.61-6.67 (br m, 1H); 7.30-7.62 (m, 6H); 7.88-7.93 (br m, 1H); 8.58-8.65 (br m, 1H). MS (APCI) (M+H)+ at m/z 470.Anal calcd for C24H27N3S1O5: C, 61.39; H, 5.80; N, 8.95. Found: C, 61.51; H, 5.87; N, 8.68., 129799-15-1

129799-15-1 Methyl 1-Boc-piperazine-2-carboxylate 2756818, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Abbott Laboratories; US2004/116518; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5308-25-8, 1-Ethylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5308-25-8, 1-(Bromomethyl)-4-nitro-2-(trifluoromethyl)benzene (34 g, 120 mmol) obtained in Step (1) above was stirred in a solvent of dichloromethane (300 mL). The reaction solution was added with 1-ethylpiperazine (15.97 mL, 126 mmol) and DIPEA (27.2 mL, 156 mmol), followed by stirring for about 3 hours at room temperature. The reaction mixture was diluted with dichloromethane, washed with a saturated aqueous sodium bicarbonate solution and saline. The organic layer thus obtained was dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to obtain the title compound (21.7 g, 57%). 1H-NMR Spectrum (300 MHz, DMSO-d6): delta 8.52 (d, 1H), 8.40 (s, 1H), 8.09 (d, 1H), 3.71 (s, 2H), 2.35 (m, 10H), 1.00 (t, 3H). MS (ESI+, m/z): 318 [M+H]+

As the paragraph descriping shows that 5308-25-8 is playing an increasingly important role.

Reference£º
Patent; HANMI PHARM. CO., LTD.; Bae, In Hwan; Han, Sang Mi; Kwak, Eun Joo; Ahn, Young Gil; Suh, Kwee Hyun; US2015/191450; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

170911-92-9, tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

mCPBA (<77% pure) (8.8 mg, 0.039 mmol) in DCM (0.5 ml) was added to a stirred solution of 3-(8-methyl-2-(methylthio)-5-oxo-5,8-dihydropyrido[2,3-d]pyrimidin-6-yl)phenyl acetate (11.6mg, 0.034 mmol) in toluene (1.0 mL) at RI under nitrogen. After 15 mi DIPEA (0.018 mL, 0.102 mmol) and tert-butyl 4-(4-aminophenyl)piperazine-1-carboxylate (10.4 mg, 0.037 mmol) were added, successively, and the temperature was increased to 60 C. After 16 h, the reaction mixture wascooled to RI and was loaded directly onto a KP-NH column and purified by flash chromatography (0-100%, EtOAc in cyclohexane; then 10% MeOH in EtOAc) to give the title compound (9.7 mg, 54%) as a yellow solid. LCMS (MethodA) : RT = 1.25 mi m/z = 529 [M+H]. 170911-92-9, The synthetic route of 170911-92-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ALMAC DISCOVERY LIMITED; ROUNTREE, James Samuel Shane; O’DOWD, Colin Roderick; BURKAMP, Frank; BELL, Mark Peter; WO2015/19037; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics