Month: February 2021

70261-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.70261-82-4,4-(4-Methylpiperazin-1-ylmethyl)phenylamine,as a common compound, the synthetic route is as follows.

Compound 2 is synthesized by reacting compound 2- A with 2-B using the conditions indicated above. Compound 2-C is then reacted with compound 2-D using the reaction conditions shown to afford the desired product (Compound 2). Purification using standard techniques (e.g., silica gel chromatography or prep-HPLC) as needed.

70261-82-4 4-(4-Methylpiperazin-1-ylmethyl)phenylamine 3153996, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; TOLERO PHARMACEUTICALS, INC.; SIDDIQUI-JAIN, Adam; WARNER, Steven L.; FLYNN, Paul; BEARSS, David J.; FOULKS, Jason Marc; TOMIMATSU, Nozomi; FUJIMURA, Ken; UMEHARA, Hiroki; NONOYAMA, Akihito; KIGUCHIYA, Akihito; (441 pag.)WO2019/195753; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

59878-57-8, 1-(Cyclopropylcarbonyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of compound 19 (100 mg, 0.33 mmol) in anhydrous DMF (3 mL) was added appropriate amine (0.43 mmol), EDC (82 mg, 0.43 mmol), 1-hydroxybenzotriazole monohydrate (66 mg, 0.43 mmol), and triethylamine (43 mg, 0.43 mmol). The reaction mixture was stirred at rt overnight, and partitioned between methylene chloride and brine. The organic phase was washed with brine, water, and concentrated. The residue was separated by HPLC to provide compounds 20. For compounds 20f, 20g, and 20h whose syntheses involved the use of BOC-protected amine, the coupling product was then treated with TFA (0.5 ml) in CH2Cl2 (2 mL) at rt for 1 h. Removal of the volatiles provided the crude 20 that can be further purified by HPLC to give the title products., 59878-57-8

As the paragraph descriping shows that 59878-57-8 is playing an increasingly important role.

Reference£º
Article; Zhu, Gui-Dong; Gong, Jianchun; Gandhi, Viraj B.; Liu, Xuesong; Shi, Yan; Johnson, Eric F.; Donawho, Cherrie K.; Ellis, Paul A; Bouska, Jennifer J.; Osterling, Donald J.; Olson, Amanda M.; Park, Chang; Luo, Yan; Shoemaker, Alexander; Giranda, Vincent L.; Penning, Thomas D.; Bioorganic and Medicinal Chemistry; vol. 20; 15; (2012); p. 4635 – 4645;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A reaction mixture of 54 5-fluoro-2-nitroanisole (1.5 g, 8.7 mmol), 55 1-methylpiperazine (1.0 g, 10.5 mmol) and 56 potassium carbonate (2.4 g, 17.4 mmol) in 40 N,N-dimethylformamide (DMF, 5 mL) was heated to 80 C. for 18 hours, and after cooling to room temperature, 50 mL 48 water was poured into the reaction, and filtered to give the precipitate, which was used directly in the next step. Under a hydrogen atmosphere, the precipitate was dissolved in 30 mL 43 methanol, 57 Raney nickel (200 mg) was added, and the mixture was reacted under the hydrogen atmosphere at room temperature for 5 hours. After filtration, the filtrate was collected and purified by column chromatography to give the product 58 2-methoxy-4-(4-methylpiperazin-1-yl)aniline 1.6 g, yield 85%. LC-MS(APCI): m/z=221.3 (M+1)., 109-01-3

The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shenzhen TargetRx, Inc.; Wang, Yihan; Ren, Xingye; Jin, Jian; Li, Huanyin; Ai, Yixin; (162 pag.)US2019/152954; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

13754-38-6, 1-Benzoylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: An oven-dried pressure tube (15 mL) was charged with a magnetic stir bar, catalyst (5 mmol%), ligand (20 mmol%). The solvent (1.2 mL) was then added. Afterwards methyl sulfinates (0.30 mmol, 1 equiv) and amine (0.6 mmol, 2 equiv) were subsequently added into the reaction mixture. The reaction was stirred under an argon atmosphere at 100 for 15 h. After cooling to room temperature, the reaction mixture was directly removed under reduced pressure and subjected to flash column chromatography in petroleum ether/ethyl acetate to obtain the desired products., 13754-38-6

As the paragraph descriping shows that 13754-38-6 is playing an increasingly important role.

Reference£º
Article; Li, Gang-Jian; Pan, You-Lu; Liu, Yan-Ling; Xu, Hai-Feng; Chen, Jian-Zhong; Tetrahedron Letters; vol. 60; 46; (2019);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.154590-35-9,tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.

8-ethyl-2-(methylsulfiotanyl)-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-one (120 mg, 0.38 mmol) and 4-(4-amino-2-fluorophenyl)piperazine-l-carboxylic acid tert-butyl ester (1 13 mg, 0.38 mmol) were stirred at 120 C for 3 h. The reaction mixture was purified by silica gel column chromatography using hexane:ethyl acetate (3:2). The isolated product was recrystallized from isopropanol to give the title compound (45 mg, 0.08 mmol, 21%) as a pale yellow solid. ESMS m/z 545 (M+H)+.

154590-35-9, 154590-35-9 tert-Butyl 4-(4-amino-2-fluorophenyl)piperazine-1-carboxylate 16203630, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio G.; VOLLRATH, Benedikt; WADE, Warren; WO2010/71846; (2010); A2;,
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Piperazines – an overview | ScienceDirect Topics

142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: General procedure for the synthesis of compounds (8a, 8b).A solution of anhydrous piperazine (5, 8.6 g, 0.1 mol) and piperazine dihydrochloride (6, 31.8 g 0.2 mol) in ethanol (80 mL) were heated with vigorous stirring at 75 C for 2 h. Then a solution benzylchloride (13.9 g, 0.11 mol) or benzoyl chloride (15.4 g,0.11 mol) was added dropwise over a period of 40 min to the hotsolution. The reaction mixture was refluxed for another 2 h, the progress of the reaction was monitored by TLC. The mixture wascooled and the precipitated piperazine dihydrochloride 6 was collected and washed three times with ethanol. The filtrate combined with the washes was concentrated in vacuo to give the N-benzylpiperazineor N-benzoylpiperazine hydrochloride which was then treated with 6 M NaOH to pH > 12. The aqueous layerof crude N-benzylpiperazine or N-benzoylpiperazine was extractedinto CH2Cl2 (3 50 mL). The combined organic extracts were driedover Na2SO4 and concentrated in vacuo. The crude oily product was purified by flash column chromatography on silica gel (MeOHCH2Cl21:3) to give 8a (18.4 g, 95%) or 8b (17.8 g, 94%).Data for 8a [21]: 1H NMR (500 MHz, CDCl3): 7.34-7.28 (m, 5H,Ph), 3.57 (s, 2H, OBn), 3.23 (s, 4H, piperazine-H), 2.77 (s, 4H,piperazine-H). MS (ESI): m/z = 177 [M + H]+. Spectroscopic dataare according to the literature [21].Data for 8b [22]: 1H NMR (500 MHz, CDCl3): 7.40 (s, 5H, Ph-H),3.78 (s, 2H), 3.42 (s, 2H), 2.40-3.10 (m, 5H). MS (ESI): m/z = 191 [M+ H]+. Spectroscopic data are according to the literature [22]., 142-64-3

As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.

Reference£º
Article; Wang, Jin; Xia, Fei; Jin, Wen-Bin; Guan, Jin-Yan; Zhao, Hang; Bioorganic Chemistry; vol. 68; (2016); p. 214 – 218;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-60-6,(R)-1-Boc-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

(2R)-l-(ter^-Butoxycarbonyl)-4-ethylpiperazine-2-carboxylic acid; To (2i?)-l-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.406 g) and Na2CO3 (2.59 g) was added dry EtOH (28 ml) then ethyl iodide (0.54 ml) and the mixture heated at reflux for 18 h under argon. The solvent was then removed under reduced pressure and 5percentMeOH/DCM (40 ml) was added and stirred for 1 hour in a sealed flask. The solution was filtered and washed with dichloromethane (2 x 1OmL). The filtrate was then placed directly onto a 120g-silica cartridge and was purified using eluent 10-70percent MeOH/DCM. After evaporation, the product was isolated as a white foam (1.00 g), which was used without further purification.

278788-60-6, The synthetic route of 278788-60-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67401; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.

A mixture of 1-bromo-3-(difluoromethyl)-5-fluoro-benzene (ig, 4.44 mmol) and 1- cyclopropylpiperazine (2.80 g, 22.22 mmol) was microwaved at 200 C for 1 h. Pumped down solvent and purified the crude mixture by ISCO purification (40g silica; 0 % to 5% to 30% of MeOH in DCM) to provide 1-[3-bromo-5-(difluoromethyl)phenyl]piperazine (920 mg, 89%). ?H NMR (300 MHz, CD3OD) oe 7.20 (s, 1H), 7.09 (s, 1H), 7.05 (d, J = 1.0 Hz, 1H), 6.66 (t, J = 56.1 Hz, 1H), 3.20 (dd, J = 6.2, 4.0 Hz, 4H), 2.98 (dd, J = 6.2, 4.1 Hz, 4H) ppm. ESI-MS m/z calc. 290.02, found 291.19 (M+1)+; Retention time: 0.63 minutes., 20327-23-5

The synthetic route of 20327-23-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; VERTEX PHARMACEUTICALS INCORPORATED; DAVIES, Robert, J.; CAO, Jingrong; COCKERILL, Meghan, Elise; COLLIER, Philip, Noel; DENINNO, Michael, Paul; DOYLE, Elisabeth; FRANTZ, James, Daniel; GAO, Huai; GOLDMAN, Brian, Anthony; GREY, Ronald, Lee; GRILLOT, Anne-laure; GU, Wenxin; HENDERSON, James, A.; IRARRAZAVAL, Raul Eduardo, Krauss; KOLPAK, Adrianne, Lynn; LIAO, Yusheng; MAGAVI, Sanjay Shivayogi; MALTAIS, Francois; MESSERSMITH, David; PIERCE, Albert, Charles; PEROLA, Emanuele; RYU, Elizabeth Jin-Sun; SYKEN, Joshua; WANG, Jian; (706 pag.)WO2016/197009; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Step 1: 3-(S)-Methyl-piperazine-1-carboxylic Acid Tert-Butyl Ester Triethylamine (3 g, 4.2 mL, 30 mmol) was added to a solution of 2-(S)-methyl piperazine (2 g, 20 mmol) in dichloromethane (40 mL) followed by di-tert-butyl-dicarbonate (4.8 g, 22 mmol). The reaction mixture was stirred at room temperature for 20 h. The mixture was diluted with dichloromethane and washed with saturated aqueous sodium bicarbonate and brine and dried over sodium sulfate. The crude product was purified using a short plug of silica gel using hexane/ethyl acetate (1:1). 1H-NMR (CDCl3) delta: 1.03 (3H, d), 1.45 (9H, s), 1.65 (1H, s), 2.35-2.42 (1H, m), 2.66-2.80 (3H, m), 2.92-2.95 (1H, m), 3.92 (2H, br s). ESI-MS m/z: 201(M+1).

74879-18-8, 74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Luly, Jay R.; Nakasato, Yoshisuke; Ohshima, Etsuo; Harriman, Geraldine C.B.; Carson, Kenneth G.; Ghosh, Shomir; Elder, Amy M.; Mattia, Karen M.; US2005/70549; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 l-Isopropyl-4-(5-niotatro-pyriotadiotan-2-yl)-piotaperaziotane [00408] To a solution of 2-chloro-5-mtropyridme (2 5g, 15 7mmol) m THF (25mL), are added1-isopropylpiperazme (2 Olg, 15 7mmol) and K2CO3 (3 25g, 23 6mmol) The reaction mixture is stirred at 500C for 4 hours and then at 7O0C overnight The solvent is removed in vacuo and the resultant orange solid is triturated using 10 1 petroleum ether-diethyl ether The isolated compound (3 7g, 94percent) is used m the next step without further purification, 4318-42-7

4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics