Month: February 2021

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.39539-66-7,4-Methylpiperazine-1-carbonyl chloride,as a common compound, the synthetic route is as follows.

Example 18 : 2,3-Dichloro-N-((1S,2S)-1-{[(4-methylpiperazin-1-yl)carbonyl]amino}-2,3- dihydro-lH-inden-2-yl)-4H-thienof3, 2-blpyrrole-5-carboxamide; To a solution of N-[(1S,2S)-1-amino-2,3-dihydro-1H-inden-2-yl]-2,3-dichloro-4H- thieno [3, 2-b] pyrrole-5-carboxamide (Method 9, 240 mg, 0. 5 mmol) and Et3N (101 mg, 1. 0 mmol) in DCM (4 mL) was added a solution of 4-methyl-1-piperazine carbonyl chloride (100 mg, 0. 5 mmol) in DCM (1 mL). The reaction was stirred at ambient temperature for 2 hours, washed with saturated Narc03 (1 mL), water (1 mL), brine (1 mL) and dried (MgS04). The volatiles were removed by evaporation under reduced pressure to give the title compound (110 mg, 45%) as a foam. MS m/z (M-H)-491.

39539-66-7, As the paragraph descriping shows that 39539-66-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/74531; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

31166-44-6, 1-Cbz-Piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

PIPERAZINE-L-CARBOXYLIC acid benzyl ester (1.03 g, 4. 68 mmol. 1.0 eq. ) and 4- TETRAIDROPIRANIL aldeide (0.8 mg, 7. 0 mmol, 1. 5 eq. ) are dissolved in 20 ml of anhydrous DCM. Na (OAC) 3BH (1. 48 g, 7.0 mmol, 1. 5 eq.) are added to this opalescent solution. The reaction is left under magnetic stirring and under a nitrogen atmosphere at room temperature for 2 hours. When the reaction is completed the solvent is removed by evaporation under reduced pressure. AcOEt (20 mL) and a IN solution OF NAOH (20 mL) are added and the biphasic system transferred to a separatory funnel. The phases are separated and the organic phase is washed with water and brine, dried on NASO,}, FILTERED and the solvent removed by evaporation under reduced pressure. 4- (Tetrahydro-pyran-4-ylmethyl)-piperazine-1-carboxylic acid benzyl ester (20) is obtained as a colourless oil (1. 3 g, 4. 08 mmol, yield = 87percent) H1 NMR (No., DMSO-D6, 300 MHZ) : 1.10 (qd, 2H, He, J= 6.3, 13.5 Hz) ; 1.59 (d, 2H, HD, J = 12. 6 Hz); 1.72 (M, 1H, HE) ; 2.30 (m, 4H, Hh); 2.63 (m, 2H, Hl); 3.23-3. 37 (m, 4H+2H, Hg + Hb), 3.80-3. 84 (M, 2H, Ha), 5.07 (s, 2H, PHCH2) ; 7.31-7. 40 (M, 5H, ArH)., 31166-44-6

31166-44-6 1-Cbz-Piperazine 643495, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; MENARINI RICERCHE S.P.A.; WO2004/94412; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

129799-08-2, 1-tert-Butyl 3-methyl piperazine-1,3-dicarboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of /ert-butyl (2-oxoethyl)carbamate (4.89 g, 30.7 mmol) in 1,2- dichloroethane (50 mL) was added to a solution of l-(tert-butyl) 3-methyl piperazine- 1,3- dicarboxylate (5 g, 20.5 mmol) in l,2-dichloroethane (25 mL). The solution stirred at 25 C under nitrogen atmosphere for 30 min. Sodium triacetoxyborohydride (8.69 g, 41.0 mmol) was added, and the resulting mixture stirred at 25 C for 15 h. The reaction was quenched by the addition of water (50 mL) at 25 C. The resulting mixture was extracted with dichloromethane (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous sodium sulfate, and the solids were filtered out. The filtrate was concentrated under vacuum. The residue was purified by silica gel chromatography (eluting with 1 : 1 ethyl acetate/petroleum ether) to afford l-ter/-butyl 3- methyl 4-(2-(/er/-butoxycarbonylamino)ethyl)piperazine-l,3-dicarboxylate as yellow oil (5.1 g, 64%). LCMS (ES, m/z): 388 [M+H]+.

129799-08-2, The synthetic route of 129799-08-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; FORMA THERAPEUTICS, INC.; MARTIN, Matthew W.; BUCKMELTER, Alexandre Joseph; (158 pag.)WO2019/222468; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.

To a solution of 1-(2-hydroxyethyl) piperazine (1.0g, 7.686mmol) in dichloromethane (25mL) were added di-tert butyl dicarbonate (2.013g, 9.223mmol) and triethylamine (TEA, 2.130g, 15.372mmol). The reaction mixture was stirred at room temperature for 12h, then washed with 3% HCl aqueous (2¡Á50mL), saturated NaHCO3 aqueous (2¡Á50mL), brine (2¡Á50mL). The resulting organic layer wasdried over Na2SO4, filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with dichloromethane/methanol (40:1) to form 1-Boc-4-(2-hydroxyethyl)-piperazine a colorlessoil (1.592g, 90% yield).

103-76-4, As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.

Reference£º
Article; Hu, Caijuan; Su, Hao; Luo, Jinghan; Han, Li; Liu, Qingyin; Wu, Wenxi; Mu, Yu; Guan, Peipei; Sun, Tiemin; Huang, Xueshi; Bioorganic and Medicinal Chemistry; vol. 26; 23-24; (2018); p. 6035 – 6049;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.692058-21-2,1-Boc-4-(2,2,2-trifluoroethyl)piperazine,as a common compound, the synthetic route is as follows.

Hydrogen chloride gas was bubbled through a solution of tert-butyl 4- (2, 2, 2-TRIFLUOROETHYLPIPERAZINE-1-CARBOXYLATE (8 g) in ethyl acetate (50 ml) during 1.5 hours. A precipitate formed as carbon dioxide gas was evolved. The precipitate was collected by filtration, washed with ethyl acetate and dried under vacuum. There was thus obtained 1- (2, 2, 2-trifluoroethyl) piperazine hydrochloride (7 g); NMR Spectrum : (DMSOd6 and CF3CO2D) 2.85 (m, 4H), 3.1 (m, 4H), 3.35 (q, 2H), 692058-21-2

The synthetic route of 692058-21-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/41829; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

5521-38-0, 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5521-38-0

Reference Example 19b 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol 2-[4-(4-amino-phenyl)-piperazin-1-yl]-ethanol is prepared by catalytic hydrogenation of 2[4-(4-nitrophenyl)piperazine-1-yl]-ethanol (prepared as in Reference Example 19a) as described in Reference Example 13b

5521-38-0 2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol 2763936, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Pierson, Edward; Sohn, Daniel; Haeberlein, Markus; Davenport, Timothy; Chapdelaine, Marc; Horchler, Carey; McCauley, John P.; US2003/13708; (2003); A1;; ; Patent; Chapdelaine, Marc; Davenport, Timothy; Haeberlein, Markus; Horchler, Carey; McCauley, John; Pierson, Edward; Sohn, Daniel; US2004/110745; (2004); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

General procedure: General Procedure 2c (1472) 1.0 equivalent of the respective intermediate, 1.0 equivalent of 1-hydroxy-1H-benzotriazole hydrate, 2.0 equivalents of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 3.0 equivalents of triethylamine and 1.2 equivalents of the amine were stirred in tetrahydrofuran at 25 C. for 18 h. Water was added to the reaction mixture. The solid was filtered off with suction, washed with water and diethyl ether and dried.

13754-38-6, 13754-38-6 1-Benzoylpiperazine 762654, apiperazines compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharma Aktiengesellschaft; BOTHE, Ulrich; SIEBENEICHER, Holger; SCHMIDT, Nicole; ROTGERI, Andrea; BOeMER, Ulf; RING, Sven; IRLBACHER, Horst; GUeNTHER, Judith; STEUBER, Holger; LANGE, Martin; SCHAeFER, Martina; (191 pag.)US2016/311833; (2016); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13754-38-6,1-Benzoylpiperazine,as a common compound, the synthetic route is as follows.

To a solution of amine 4 (1.82 g, 9.56 mmol) inDMF (20 mL) at 0 C was added K2CO3 (3.61 g, 26.13 mmol) followed by the addition of compound 3(1.96 g, 8.67 mmol) and the reaction mixture was stirred overnight at 60 C. After completion of thereaction (TLC analysis), the mixture was cooled to room temperature and diluted with ethyl acetate(75 mL). The solution was washed with H2O (30 mL ¡Á 3), brine (20 mL ¡Á 2) and the organic layer wasseparated, dried over Na2SO4 and evaporated under vacuum to afford the title compound 5 as as lightyellow amorphous solid (2.16 g, 74%), m.p. 196-197 C. IR (KBr): 3063, 2999, 2929, 2233, 1670,1622, 1596, 1578, 1457, 1430, 1389, 1341, 1294, 1249, 1155, 1094, 1072 cm-1. 1H-NMR (CDCl3): delta3.47 (br. s, 4H, -CH2NCH2-), 3.79 (br. s, 4H, -CH2NCH2-), 6.99 (dd, 1H, J = 2.6, 9.4 Hz, Ar-H), 7.14(d, 1H, J = 2.7 Hz, Ar-H), 7.40-7.48 (m, 5H, Ar-H), 8.19 (d, 1H, J = 9.5 Hz, Ar-H). 13C-NMR(CDCl3): delta 46.44, 46.84, 110.05, 115.66, 118.89, 126.93, 127.10, 127.79, 128.67, 130.33, 134.69,137.79, 153.10, 170.61. Anal. Calcd for C18H16N4O3: C, 64.28; H, 4.79; and N, 16.66. Found: C,64.22; H, 4.84; and N, 16.60.

13754-38-6, The synthetic route of 13754-38-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Ba-Salem, Abdullah O.; Ullah, Nisar; Shaikh, M. Nasiruzzaman; Faiz, Mohamed; Ul-Haq, Zaheer; Molecules; vol. 20; 5; (2015); p. 7807 – 7819;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

109-07-9, 2-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Reference Example 2 Synthesis of t-butyl 3-methylpiperazine-1-carboxylate Under ice-cooling, 15 ml of tetrahydrofuran (THF) solution containing 10.9 g of DIBOC was added to 150 ml of THF solution containing 10 g of 2-methylpiperazine.. After stirring overnight, the solvent was evaporated under reduced pressure.. The residue was mixed with water and extracted with ethyl acetate, and then the organic layer was washed and dried and the solvent was evaporated under reduced pressure to obtain 8.94 g of the title compound as a yellow oily substance.

109-07-9, As the paragraph descriping shows that 109-07-9 is playing an increasingly important role.

Reference£º
Patent; Yamanouchi Pharmaceutical Co. Ltd.; US6673799; (2004); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-07-9,2-Methylpiperazine,as a common compound, the synthetic route is as follows.

Example 6 A reaction was carried out as described for Example 1, except that the solvent was changed from 44 g of 1-butanol to 44 g of ethanol (water content 0.06 wt%). After stirring at 0C for 2 hours, the reaction solution was analyzed. As a result, the reaction yield of 1-benzyloxycarbonyl-3-methylpiperazine was 83.4% (based on the amount of 2-methylpiperazine)., 109-07-9

The synthetic route of 109-07-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Toray Fine Chemicals Co., Ltd.; EP1548010; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics