84477-85-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.84477-85-0,Benzyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
3-Methyl-l-piperazinecarboxylic acid, phenylmethyl ester (380 mg), the product from example 13 part (a) (400 mg) and MgSO4 were stirred in THF (30 ml) for 20 h. Sodium triacetoxy borohydride (510 mg) was added and stirred for 2 h. The mixture was quenched with water, extracted with EtOAc, washed with water and brine, dried (MgSO4), filtered and evaporated in vacuo. The residue was purified by chromatography on silica with 20%EtOAc/isohexane as eluent to yield the sub-title compound (500 mg).MS: APCI (+ve): 490 (M+l) 1H NMR (DMSO-d6) 6 7.34 (m, 6H), 7.23 (dd, IH), 6.88 (d, IH), 5.08 (dd, 2H), 4.68 (s, 2H),3.80 (m, IH), 3.66 (m, IH), 3.34 (m, 2H), 3.21 – 3.08 (m, IH), 3.05 – 2.81 (m, IH), 2.65 (m,IH), 2.46 (m, IH), 2.14 (m, IH), 1.41 (s, 9H), 1.03 (d, 3H)
84477-85-0 Benzyl 3-methylpiperazine-1-carboxylate 10421542, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/56752; (2006); A1;,
Piperazine – Wikipedia
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