Brief introduction of 4-(4-Ethylpiperazin-1-yl)phenylamine

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 46; 8-Ethyl-2- { [4-(4-ethylpiperazin- 1 -yl)phenyl] amino } -4-methyl-6-phenylpyrido [2,3 – d]pyrimidm-7(8H)-one[00242] 8-Ethyl-4-methyl-2-(methylsulfonyl)-6-phenylpyrido[2,3-cdpyrimidin-7(8H)- one (275 mg, 0.80 mmol) and 4-(4-ethylpiperazin-l-yl)aniline (197 mg, 1.2 equiv.) were added to dimethyl sulfoxide (5 mL) and the resulting mixture was heated to 100 0C and stirred overnight. After cooling to room temperature, the reaction was partitioned between aqueous and organic layers with ethyl acetate and H2O, organic layer was dried with anhydrous magnesium sulfate, filtered and evaporated, and directly applied to prep-LC to EPO provide the title compound in (210.0 mg, 56 % yield): 1H NMR (400 MHz, CDCl3): delta 7.80(s, IH), 7.62 (d, 2H), 7.60 (d, 2H)5 7.40 (m, 2H), 7.18 (s, 1eta), 6.95 (d, 2H)5 4.50 (q, 2H)5 3.22(m, 4H)5 2.70 (m, 4H)5 2.60 (s, 3H)5 2.50 (m, 2H)5 1.40 (t, 3H)5 1.20 (t, 3H); MS (EI) forC28^2N6O: 469.10 (MH4)., 115619-01-7

The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; EXELIXIS, INC.; WO2007/44698; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics