With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
Example 21 7-[(4-tert-Butoxycarbonylpiperazin)-1-yl]-1-ethyl-8-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine-2-one An oven-dried flask, charged with 7-bromo-1-ethyl-8-methoxy-2,3,4,5-tetrahydro-1H-1-benzazepine-2-one (268 mg, 0.90 mmol), benzyl 1-piperazinecarboxylate (201 mg, 1.08 mmol), Pd(OAc)2 (20.16 mg, 0.09 mmol, 10 mol percent), BINAP (84.12 mg, 0.134 mmol) was purged with argon for 5 min. Anhydrous toluene (1.5 mL) was added via syringe. The flask was opened and sodium tert-butoxide (120.0 mg, 1.26 mmol) was added in one portion. After purging with argon for 3 min, the reaction mixture was stirred and heated at 100¡ã C. for 2 hrs. TLC indicated that the starting material has been consumed. The reaction mixture was allowed to cool to ambient temperature, poured into water, extracted with ethyl acetate, dried over Na2SO4, filtered and evaporated to dryness. Purification of the crude product by flash chromatography on silica gel column eluted with MeOH/DCM (10percent of MeOH in DCM) gave the title compound as brownish foam (266 mg, 73percent). M.P.: amorphous compound MS (FAB): calcd for C22H33N3O4 403.52; found m/e 404 (M+1)+., 31166-44-6
The synthetic route of 31166-44-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Antex Pharma Inc.; US6514965; (2003); B1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics