With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.132710-90-8,1-Boc-4-(3-hydroxypropyl)piperazine,as a common compound, the synthetic route is as follows.,132710-90-8
A mixture of tert-butyl 4-(3-hydroxypropyl)piperazine-l-carboxylate (1.52 g, 6.2 mmol), Ph3P (2.46 g, 9.4 mmol), I2 (2.40 g, 9.4 mmol) and imidazole (1.28 g, 18.6 mmol) in DCM (100 mL) was stirred at room temperature for 5 h. The mixture was diluted with DCM and the organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered, and evaporated under vacuum to give a residue which was purified by column chromatography (silica gel, PE : EtOAc = 5 : 1) to afford tert-butyl 4-(3-iodopropyl)piperazine-l-carboxylate (1.10 g, 50% ) as a colorless oil.
The synthetic route of 132710-90-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; PRINCIPIA BIOPHARMA INC.; BRAMELD, Kenneth Albert; VERNER, Erik; (122 pag.)WO2016/191172; (2016); A1;,
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