With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31166-44-6,1-Cbz-Piperazine,as a common compound, the synthetic route is as follows.
Tert-butyl N – [(6-bromohexylamino) – (tert-butoxycarbonylamino) methylene] carbamate (4.23 g) was dissolved in N, N- dimethylformamide (21 mL). To this was added benzylpiperazine-1-carboxylate (2.55 g) and potassium carbonate (1.66 g) sequentially at room temperature. Thereafter, the mixture was stirred at 50 ¡ã C. overnight. It was cooled to room temperature. The resulting solution was poured into water and extracted with ethyl acetate. The combined organic layer was dried over anhydrous magnesium sulfate. It was then filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography to give the title compound (5.04 g, yield 90percent).
31166-44-6, As the paragraph descriping shows that 31166-44-6 is playing an increasingly important role.
Reference£º
Patent; NIPPON SODA COMPANY LIMITED; IHORI, YOICHI; INOUE, SHUJI; SHIBAYAMA, KOTARO; KANG, CHANG-KYUNG; SHIINOKI, YASUYUKI; NISHIMURA, SATOSHI; (65 pag.)JP2016/222654; (2016); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics