With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
Under argon protection,Add to 250mL three-neck bottleLithium tetrahydrogen aluminum (1.36g, 36mmol)Cool down to about 0 C, add THF (100 mL), drop,Then a solution of (R)-3-methylpiperazine-1-carboxylic acid tert-butyl ester (3.60 g, 18 mmol) in THF (10 mL).The temperature was controlled at -5 to 0 C, and the mixture was heated to 60 C for 2 h. TLC monitors the reaction.The reaction of the raw materials was complete, and the temperature was lowered to about 0 C, and water (1.37 mL) was slowly added dropwise.The aqueous sodium hydroxide solution (2N, 1.37 mL) was quenched with water (2.74 mL).Stir for 5min,Filtration, the filter cake was rinsed with 15 mL of methanol, and the filtrate was concentrated under reduced pressure at 40 C to give 2 g of colorless oil. The crude product was purified by column chromatography, using neutral alumina as an adsorbent, eluting with DCM/MeOH=20/1.The product was collected and concentrated to give 1.3 g of a colorless oil, yield: 65%.
163765-44-4, The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Beijing Purunao Bio-technology Co., Ltd.; Zhang Peilong; Shi Hepeng; Lan Wenli; Song Zhitao; (250 pag.)CN108707139; (2018); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics