Downstream synthetic route of (R)-Piperazine-2-carboxylic acid

As the paragraph descriping shows that 31321-68-3 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31321-68-3,(R)-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

S-127 (200 mg) was converted to S-128 using B0C2O in the presence of NaOH in dioxane and H2O. The reaction was stirred at room temperature for 12 hours. After purification, 400 mg of S-128 was obtained., 31321-68-3

As the paragraph descriping shows that 31321-68-3 is playing an increasingly important role.

Reference£º
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (207 pag.)WO2019/136244; (2019); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics