With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34770-60-0,4-Methylpiperazin-2-one,as a common compound, the synthetic route is as follows.
Step A: To a solution of 4-bromo-benzaldehyde (1.8 g, 9.73 mmol), 4-methylpiperazine-2-one (1.44 g, 12.6 mmol), Pd2(dba)3 (768 mg, 0.84 mmol), Xantphos (435 mg, 0.75 mmol) and cesium carbonate (5.48 g, 16.8 mmol) in dioxan (30 mL) was added water (1 drop). The mixture was stirred under nitrogen atmosphere at 90C for 1.5 h. After cooling, the mixture was filtered. The filtrate was concentrated to dryness under vacuum. The residue was purified with silica gel chromatography to give 4-(4-methyl-2-oxopiperazine-1-yl)benzaldehyde(1.8 g, 84.8%) as white solid. MS(ESI)m/z:219[M+H+].
34770-60-0, The synthetic route of 34770-60-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chai Tai Tianqing Pharmaceutical Group Co., Ltd.; DING, Zhaozhong; WU, Hao; SUN, Fei; WU, Lifang; YANG, Ling; (60 pag.)EP3190113; (2017); A1;,
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