With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
In the following order 6.82 g (29.9 mmol) of the methylated bromo compound, 4.03 g (35.9 mmol) of the dimethyl piperazine, 13.6 g (41.9 mmol) of Cs2CO3, 1.42 g (2.99 mmol) of X-Phos (see Huang et al., J. Am. Chem. Soc., 125(2003)6653). and 0.55 g (0.6 mmol) of Pd2(dba)3 were added to 225 ml of toluene which was degassed for 4 hours prior to usage. While stirring and under a nitrogen atmosphere the temperature was raised to 100¡ã C. for 20 hours, after which it was allowed to reach room temperature. The mixture was diluted with CH2Cl2 after which it was filtered and concentrated in vacuo. The residue was put on top of a flash chromatography column (SiO2) using DMA 0.25. The combined product containing fractions yielded after concentration in vacuo 0.73 g (9percent) of the desired pure piperazine VIII-H., 21655-48-1
As the paragraph descriping shows that 21655-48-1 is playing an increasingly important role.
Reference£º
Patent; SOLVAY PHARMACEUTICALS B.V.; US2006/122189; (2006); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics