115619-01-7, 4-(4-Ethylpiperazin-1-yl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a 0.342 g of 4-(4-ethyl-piperazine-1yl)phenylamine (4d;0.00167 mol) in a dry round bottom flask was added 10 mL of 98%ethanol. The mixture was stirred at room temperature till completedissolution. Then 0.350 g of ethyl 2,4-dioxo-6-phenylcyclohexanecarboxylate(E164; previously synthesized in our lab)23 was added.The reaction mixture was refluxed for about 6 h. The reaction wasmonitored by thin layer chromatography (dichloromethane: methanol85/15). After 6 h, the heat was turned off and reaction continued to stirovernight. After reaction was completed, the reaction was adsorbed ona silica gel and purified by automated flash chromatography (dichloromethane:methanol 75/25) to yield a dark orange solid (0.7059 g,94.9%). 1H NMR (300 MHz, d- CDCl3): delta (ppm) 0.992-1.040 (t, 3H),1.115-1.163 (t, 3H), 2.474-2.498 (q, 2H), 2.600-2.633 (t, 4H),3.203-3.237 (t, 4H), 3.237 (d, 1H), 3.622-3.663 (m, 1H), 4.008-4.037(q, 2H), 5.482 (s, 1H), 6.876-6.906 (d, 2H), 7.052-7.082 (d, 2H),7.297-7.326 (m, 5H). HRMS (ESI): m/z, Calcd. for C27H33N3O3[M+H]+: 448.2589, found 448.2635
115619-01-7, 115619-01-7 4-(4-Ethylpiperazin-1-yl)phenylamine 936738, apiperazines compound, is more and more widely used in various fields.
Reference£º
Article; Ghoneim, Ola M.; Bill, Ashley; Dhuguru, Jyothi; Szollosi, Doreen E.; Edafiogho, Ivan O.; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 3890 – 3898;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics