With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.381242-61-1,1-(4-Nitro-2-(trifluoromethyl)phenyl)piperazine,as a common compound, the synthetic route is as follows.
According to scheme 1, step 2: 1-(4-nitro-2-(trifluoromethyl)phenyl)piperazine (5.0 mmol) was taken in ethyl acetate (20 mL), to this, aqueous sodium hydroxide (6.2 mmol, 30%) was added keeping the temperature 0 C, carbon disulfide (6.2 mmol) dissolved in ethylacetate (5 mL) was added drop-wise with stirring at 0 C. The reaction mixture was further stirred at room temperature for one hour to furnish a yellow solid. Solvent was distilled off and the crude was recrystallised by methanolic ether to get sodium 4-(4-nitro-2- (trifluoromethyl)phenyl)piperazine-1 -carbodithioate as a yellow powder., 381242-61-1
The synthetic route of 381242-61-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH; SHARMA, Vishanu Lal; LAL, Nand; SARSWAT, Amit; JANGIR, Santosh; BALA, Veenu; KUMAR, Lalit; RAWAT, Tara; JAIN, Ashish; KUMAR, Lokesh; MAIKHURI, Jagdamba Prasad; GUPTA, Gopal; WO2014/122670; (2014); A1;,
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