474711-89-2,474711-89-2, Piperazine-1-carboxamide hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
56c. Lambda/1-Methyl-Lambda/1-((2,6,6-trimethylcyclohex-1-en-1-yl)methyl)piperazine- 1,4-dicarboxamide3-Methyl-1 -(methyl((2,6,6-trimethylcyclohex-1 -en-1 – yl))methyl)carbamoyl)-1 H-imidazol-3-ium iodide (0.200 g, 0.470 mmol), piperazine-1-carboxamide hydrochloride (78.0 mg, 0.470 mmol) and triethylamine (0.130 ml_, 0.930 mmol) were dissolved in a 1 :4 mixture of acetonitrile: dichloromethane. The reaction mixture was stirred at room temperature under argon for 2 days. The reaction mixture was poured into saturated ammonium chloride (30 mL) and the organic layer was removed. The aqueous layer was extracted with dichloromethane (4 x 15 mL). The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The product obtained as a white solid (11 mg, 0.03 mmol, 7%) was purified by preparative plate thin layer chromatography (1000 mum thickness Sitheta2 gel, 20 cm x 20 cm plate, eluent 10:90 methanol: ethyl acetate + 0.1 % (v/v) ammonium hydroxide. Mp = 139.6-140.30C; Rf = 0.62 (10:90 methanol: ethyl acetate + 0.1 % (v/v) ammonium hydroxide); 1H-NMR (400 MHz, DMSO) delta 6.00 (s, 2H), 3.93 (s, 2H), 3.32-3.28 (m, 4H), 3.01-3.00 (m, 4H), 2.66 (s, 3H), 1.99-1.96 (m, 2H), 1.65 (s, 3H), 1.59-1.57 (m, 2H), 1.41- 1.40 (m, 2H), 0.96 (s, 6H); Mass spectrum (ESI +ve) m/z 323.0 (MH+).
The synthetic route of 474711-89-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; BIKAM PHARMACEUTICALS, INC.; GARVEY, David, S.; LAROSA, Gregory, J.; GREENWOOD, Jeremy, Robert; BREWER, Mark, L.; QUACH, Tan; COTE, Jamie, B.; BERMAN, Judd; WO2010/147653; (2010); A1;,
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