With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
74879-18-8, To a solution of 2-(S)-methylpiperazine (3.79 g, 37.9 mmol) in CHCl3 (100 ML) was trityl chloride (10.56 g, 37.9 mmol) added in one portion.The exothermic reaction was stirred at ambient temperature for two hours, the organic phase was washed three times with water, dried (MgSO4) and the solvent was evaporated at reduced pressure to give 12.5 g (96%) of a colorless foam that solidified to a crisp over night. 1H NMR (CDCl3) delta1.06 (d, J=5.5 Hz, 3 H), 1.35 (m, 1 H), 1.61 (m, 1 H), 3.01 (m, 3 H), 3.14 (m, 1 H), 3.31 (m, 1 H), 7.08 (m, 3 H), 7.16 (m, 6 H), 7.35 (m, 6 H).13C NMR (CDCl3) delta18.17, 44.46, 46.68, 51.59, 54.03, 126.26, 127.13, 127.68, 129.07 br. The racemate of the title compound is reported in Bioorg. Med. Chem. Lett. 2000, 10, 2643-2646.
74879-18-8 (S)-(+)-2-Methylpiperazine 2734219, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; Nilsson, Bjorn M.; Ringberg, Erik; US2003/232814; (2003); A1;,
Piperazine – Wikipedia
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