With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5521-38-0,2-(4-(4-Nitrophenyl)piperazin-1-yl)ethanol,as a common compound, the synthetic route is as follows.,5521-38-0
A stirred solution of 2-(4-(4-nitrophenyl)piperazin-1- yl)ethanol (1.2 g, 4.78 mmol) in ethanol (20 mL) washeated to 50 C. 10% palladium on carbon (0.254 g, 0.239 mmol) was added followed by portionwise addition of ammonium formate (1.506 g, 23.88 mmol) and the suspension was stirred for 1 hour. The suspension was filtered through Celite washing with fresh ethanol (20 mL) . Theethanol was removed in vacuo to give the title compound(1.10 g, 104 %) . ?H NMR (400 MHz, CDC13) : 3 6.81 (d, 2H),6.66 (d, 2H), 3.69 (t, 2H), 3.09 (t, 4H), 3.02 (br s,3H), 2.74 (t, 4H), 2.66 (t, 2H) . LCMS (Method C): =0.13 mi m/z = 222 [M+H].
As the paragraph descriping shows that 5521-38-0 is playing an increasingly important role.
Reference£º
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
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