With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630125-91-6,4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline,as a common compound, the synthetic route is as follows.
A mixture of (4-Trifluoromethyl-phenyl)-acetic acid (0.14 g, 0.63 mmol), 4-(4-ethyl-piperazin-1-ylmethyl)-3-trifluoromethyl-phenylamine (0.15 g, 0.52 mmol), TBTU (0.20 g, 0.63 mmol) and DIPEA (0.11 mL, 0.63 mmol) in15 anhydrous DMF (3 mL) was stirred at r.t. overnight. The reaction was poured in a saturated solution of NaHC03 andextracted with EtOAc (2 x 15 mL), the organic phase was washed with brine, dried with anhydrous Na2S04 andevaporated under vacuum. The crude was purified by flash column chromatography (DCM/MeOH 97/3) to obtain thetitle compound (0.25 g, 80%) as white solid.1H NMR (600 MHz, DMSO-dG) o ppm 0.99 (br. s., 3 H) 2.17- 2.48 (m, 8 H) 3.58 (s, 2 H) 7.73 (d, J=8.42 Hz, 1 H)20 7.81 (dd, J=9.25, 1.37 Hz, 1 H) 7.85 (dt, J=7.97, 2.06 Hz, 1 H) 8.00-8.05 (m, 2 H) 8.17 (d, J=2.02 Hz, 1 H) 10.61 (s,1 H)., 630125-91-6
630125-91-6 4-((4-Ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline 59134564, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; MENICHINCHERI, Maria; ANGIOLINI, Mauro; BERTRAND, Jay Aaron; CARUSO, Michele; POLUCCI, Paolo; QUARTIERI, Francesca; SALOM, Barbara; SALSA, Matteo; ZUCCOTTO, Fabio; WO2014/72220; (2014); A1;,
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