With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74879-18-8,(S)-(+)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
74879-18-8, (S)-2-methylpiperazine (5.00 g, 49.9 mmol) was dissolved in DCM (150 mL). A solution of boc anhydride (5.47 g, 25.0 mmol) in DCM (50 mL) was added dropwise at 0 C. The reaction mixture was stirred at rt for 2 h. The solution was filtered and concentrated under reduced pressure. Water (100 mL) was added to the residue and it was filtered again. The filtrate was saturated with K2CO3 and extracted with Et2O (3¡Á150 mL). The combined organic layers were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to provide 4.92 g title compound (49%) as a solid. 1H NMR (300 MHz, CDCl3) delta ppm 1.03 (d, J=6.3 Hz, 3H) 1.45 (s, 9H) 1.53 (br. s, 1H) 2.38 (t, J=11.8 Hz, 1H) 2.65-2.72 (m, 1H) 2.74-2.76 (m, 2H) 2.92-2.95 (m, 1H) 3.92 (br. s, 2H).
As the paragraph descriping shows that 74879-18-8 is playing an increasingly important role.
Reference£º
Patent; ASTRAZENECA AB; US2010/216812; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics