With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5464-12-0,1-(2-Hydroxyethyl)-4-methylpiperazine,as a common compound, the synthetic route is as follows.
5464-12-0, a) 1 -(2-Chloroethyl)-4-methylpiperazine (1-96) Thionyl chloride (2.4 mL; 33 mmol; 1.1 eq) was added to a solution of 2- (4- methylpiperazin-l-yl)ethan-l-ol (4 g; 29 mmol; 1 eq) in dry chloroforme (40 mL). The reaction mixture was stirred at reflux for 4 hours, then, concentrated to dryness. 1M sodium hydroxide solution (100 mL) was added and the aqueous layer was extracted with ethyl acetate (3 x 150 mL). The combined organic layers were washed with saturated sodium chloride (1 x 50 mL), dried over sodium sulfate, filtered and concentrated under reduced pressure to afford the title compound, l-(2-chloroethyl)- 4-methylpiperazine in 35percent yield (1.66 g) as an brown oil. 1H NMR (CDC13): 2.36 (s, 3H), 2.59 (m, 8H), 2.79 (t, 2H), 3.64 (t, 2H); MS (ESI+): m/z = 163.1-165.1 [M+H]+.
The synthetic route of 5464-12-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; VIVALIS; GUEDAT, Philippe; BERECIBAR, Amaya; CIAPETTI, Paola; VENKATA PITHANI, Subhash; TROUCHE, Nathalie; WO2013/171281; (2013); A1;,
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