1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of intermediate 1.2 (4g) in MeCN (100ml_) were added (S)-1-Boc-2- hydroxymethylpiperazine (3.07g) and DIPEA (3.54ml_) at RT. The reaction mixture was stirred at 80C for 28h. After cooling down, the reaction mixture was diluted with EA and washed with water (2x) and brine. The aq. layers were extracted with EA. The combined org. layers were dried over MgS04, filtrated off and evaporated to dryness. The crude was purified by CC (Biotage, SNAP 340g, solvent A: Hep; solvent B: EA; gradient in %B: 30 over 3CV, 30 to 50 over 5CV, 50 over 3CV) to afford 4g of yellow foam. LC-MS (A): tR = 0.87min; [M+H]+: 426.0., 1030377-21-9
The synthetic route of 1030377-21-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; IDORSIA PHARMACEUTICALS LTD; CAROFF, Eva; MEYER, Emmanuel; (32 pag.)WO2018/11265; (2018); A1;,
Piperazine – Wikipedia
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