With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Step 1 l-Isopropyl-4-(4-niotatro-phenyl)-piotaperaziotane[00393] To a solution of 4-fluoromtrobenzene (5g, 35 4mmol) m THF (5OmL), 1- lsopropylpiperazme (4 54g, 35 4mmol) and K2CO3 (7 35g, 53 2mmol) are added The reaction mixture is stirred at room temperature overnight The solvent is removed in vacuo and the residue is partitioned between EtOAc and water The organic layer is washed with brine, dpied over MgSO4, filtered and concentrated The crude compound is purified by silica gel column chromatography using 99 1 and 98 2 DCM NH3 (7M in MeOH) to give the title compound (8 2g, 94percent)
4318-42-7, 4318-42-7 1-Isopropylpiperazine 78013, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; GALAPAGOS N.V.; WO2007/131991; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics