With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-78-2,tert-Butyl 2-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
Intermediate 51 : (3-Methyl-piperazin- 1 -yl)-(l -m-tolyl- 1 H-[ 1 ,2,4]triazol-3-yl)-methanone 51.1 : 2-Methyl-4-(l-m-tolyl-lH-[l ,2,4]triazole-3-carbonyl)-piperazine-l-carboxylic acid tert- butyl ester 2.00 g (9.84 mmol) l-m-tolyl-lH-[l ,2,4]triazole-3-carboxylic acid was stirred with 3.30 g (10.3 mmol) TBTU and 2.50 mL (14.6 mmol) DIPEA in 30 mL DCM at RT. After 10 min, 2.05 g (9.84 mmol) 2-methyl-piperazine-l-carboxylic acid tert-butyl ester was added and the reaction mixture was stirred at RT for 12 h. The solvent was removed by distillation. The residue was taken up in water and extracted with EtOAc. The combined organic phases were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by flash chromatography (EtOAc). Yield: 4.00 g (95 %), purity: 90% ESI-MS: m/z = 386 (M+H)+ Rt(HPLC) : 1.48 min (method 8)
120737-78-2, As the paragraph descriping shows that 120737-78-2 is playing an increasingly important role.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd; WO2013/87805; (2013); A1;,
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