With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
A mixture of (R) -tert-butyl 3-methylpiperazine-1-carboxylate (300 mg, 1.5 mmol) , butyric acid (200 mg, 2.3 mmol) , EDCI (595 mg, 3.0 mmol) and HOAT (306 mg, 2.3 mmol) in DCM (10 mL) was stirred at 0 , and DIPEA (0.76 mL, 4.5 mmol) was added dropwise. After the addition, the mixture was stirred at rt for 10 h and washed with water (10 mL ¡Á 3) . The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by silica gel chromatography eluted with Petroleum ether/EtOAc (v/v) 2/1 to give (R) -tert-butyl 4-butyryl-3-methylpiperazine-1-carboxylate as colorless liquid (370 mg, 91) .1H NMR (600 MHz, CDCl3) : delta ppm 4.74-4.81, 4.34-4.41 (m, 0.5H, 0.5H) , 3.80-4.12, 3.53-3.60 (m, 2.5H, 0.5H) , 3.26-3.35, 2.75-2.98 (m, 0.5H, 2.5H) , 2.26-2.35 (m, 2H) , 1.61-1.69 (m, 2H) , 1.47 (s, 9H) , 1.13-1.24 (m, 3H) , 1.12 (t, J 7.3 Hz, 3H) and MS-ESI: m/z 215.10 [M-55] +., 163765-44-4
The synthetic route of 163765-44-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
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