With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.278788-60-6,(R)-1-Boc-Piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
(2R)-l-(ter^-Butoxycarbonyl)-4-ethylpiperazine-2-carboxylic acid; To (2i?)-l-(tert-butoxycarbonyl)piperazine-2-carboxylic acid (1.406 g) and Na2CO3 (2.59 g) was added dry EtOH (28 ml) then ethyl iodide (0.54 ml) and the mixture heated at reflux for 18 h under argon. The solvent was then removed under reduced pressure and 5percentMeOH/DCM (40 ml) was added and stirred for 1 hour in a sealed flask. The solution was filtered and washed with dichloromethane (2 x 1OmL). The filtrate was then placed directly onto a 120g-silica cartridge and was purified using eluent 10-70percent MeOH/DCM. After evaporation, the product was isolated as a white foam (1.00 g), which was used without further purification.
278788-60-6, The synthetic route of 278788-60-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67401; (2006); A1;,
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