142-64-3, Piperazine Dihydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: General procedure for the synthesis of compounds (8a, 8b).A solution of anhydrous piperazine (5, 8.6 g, 0.1 mol) and piperazine dihydrochloride (6, 31.8 g 0.2 mol) in ethanol (80 mL) were heated with vigorous stirring at 75 C for 2 h. Then a solution benzylchloride (13.9 g, 0.11 mol) or benzoyl chloride (15.4 g,0.11 mol) was added dropwise over a period of 40 min to the hotsolution. The reaction mixture was refluxed for another 2 h, the progress of the reaction was monitored by TLC. The mixture wascooled and the precipitated piperazine dihydrochloride 6 was collected and washed three times with ethanol. The filtrate combined with the washes was concentrated in vacuo to give the N-benzylpiperazineor N-benzoylpiperazine hydrochloride which was then treated with 6 M NaOH to pH > 12. The aqueous layerof crude N-benzylpiperazine or N-benzoylpiperazine was extractedinto CH2Cl2 (3 50 mL). The combined organic extracts were driedover Na2SO4 and concentrated in vacuo. The crude oily product was purified by flash column chromatography on silica gel (MeOHCH2Cl21:3) to give 8a (18.4 g, 95%) or 8b (17.8 g, 94%).Data for 8a [21]: 1H NMR (500 MHz, CDCl3): 7.34-7.28 (m, 5H,Ph), 3.57 (s, 2H, OBn), 3.23 (s, 4H, piperazine-H), 2.77 (s, 4H,piperazine-H). MS (ESI): m/z = 177 [M + H]+. Spectroscopic dataare according to the literature [21].Data for 8b [22]: 1H NMR (500 MHz, CDCl3): 7.40 (s, 5H, Ph-H),3.78 (s, 2H), 3.42 (s, 2H), 2.40-3.10 (m, 5H). MS (ESI): m/z = 191 [M+ H]+. Spectroscopic data are according to the literature [22]., 142-64-3
As the paragraph descriping shows that 142-64-3 is playing an increasingly important role.
Reference£º
Article; Wang, Jin; Xia, Fei; Jin, Wen-Bin; Guan, Jin-Yan; Zhao, Hang; Bioorganic Chemistry; vol. 68; (2016); p. 214 – 218;,
Piperazine – Wikipedia
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