109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A reaction mixture of 54 5-fluoro-2-nitroanisole (1.5 g, 8.7 mmol), 55 1-methylpiperazine (1.0 g, 10.5 mmol) and 56 potassium carbonate (2.4 g, 17.4 mmol) in 40 N,N-dimethylformamide (DMF, 5 mL) was heated to 80 C. for 18 hours, and after cooling to room temperature, 50 mL 48 water was poured into the reaction, and filtered to give the precipitate, which was used directly in the next step. Under a hydrogen atmosphere, the precipitate was dissolved in 30 mL 43 methanol, 57 Raney nickel (200 mg) was added, and the mixture was reacted under the hydrogen atmosphere at room temperature for 5 hours. After filtration, the filtrate was collected and purified by column chromatography to give the product 58 2-methoxy-4-(4-methylpiperazin-1-yl)aniline 1.6 g, yield 85%. LC-MS(APCI): m/z=221.3 (M+1)., 109-01-3
The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Shenzhen TargetRx, Inc.; Wang, Yihan; Ren, Xingye; Jin, Jian; Li, Huanyin; Ai, Yixin; (162 pag.)US2019/152954; (2019); A1;,
Piperazine – Wikipedia
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