196811-66-2, tert-Butyl 4-carbamothioylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
All of the alpha-bromoketone above and 4-thionocarbonylpiperazine-1-carboxylic acid tert- butyl ester {J. Med. Chem., 1998, 5037-5054, 917 mg, 3.73 mmol) were refluxed in 36 ml_ THF at 70 C for 2 h, under N2. The precipitate was filtered and the filtrate evaporated to give yellow solids. Flash column chromatography (silica, 5/1 petroleum ether – EtOAc) gave 624 mg of light yellow solids. Chromatography of the precicpitate (silica, 2/1 petroleum ether – EtOAc) gave 32 mg more of compound. Total yield is 44%.1 H NMR (CDCI3) delta ppm: 1.46 (s, 9H), 2.43 (s, 3H), 3.42, (m, 4H), 3.54 (m, 4H), 3.90 (s, 3H), 7.68 and 8.04 (ABq, 4H)., 196811-66-2
As the paragraph descriping shows that 196811-66-2 is playing an increasingly important role.
Reference£º
Patent; MEDIVIR AB; WO2008/114054; (2008); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics