With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.192130-34-0,tert-Butyl 4-(2-aminoethyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
REFERENCE SYNTHETIC EXAMPLE 9 Synthesis of AD23-04 1) Synthesis of AD23-01 5.0 g (17.5 mmol) of AD18-04 was heated with 50 mL of thionyl chloride for 1 hour with reflux, and the reaction solution was concentrated under reduced pressure. The resulting acid chloride was used directly in the subsequent reaction. 3.4 g (15 mmol) of tert-butyl 4-(2-aminoethyl)tetrahydro-1 (2H)-pyrazinecarboxylate in 100 mL of methylene chloride was stirred with 100 mL of water, 2 g of sodium hydrogen carbonate and the acid chloride at room temperature for 1 day. After addition of 100 mL of methylene chloride, the reaction solution was allowed to separate, and the organic layer was dried over anhydrous sodium sulfate and filtered. The filter cake was mixed with 10 g of silica gel, and from the silica gel mixture, 4.24 mg (8.5 mmol, yield 49percent) of AD23-01 was purified by column chromatography (silica gel 125 g, methylene chloride : methanol = 1:0 to 5:1)., 192130-34-0
The synthetic route of 192130-34-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Nissan Chemical Industries, Ltd.; EP2439204; (2012); A1;,
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