13889-98-0, 1-Acetylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation of ethyl 2-(4-acetylpiperazin-l-yl)-2-phenylacetate (154). Ethyl 2-bromo-2-phenylacetate (0.22 ml, 1.23 mmol) was dissolved in acetonitrile (4 ml) and DIPEA (0.28 ml, 1.60 mmol) and 1- (piperazin- l-yl)ethanone (0.21 g, 1.60 mmol) were sequentially added. The reaction was stirred at room temperature overnight. The solvent was evaporated and the residue was purified by flash chromatography (DCM/Acetone = 9/1) to obtain ethyl 2-(4-acetylpiperazin-l-yl)-2- phenylacetate (341 mg, 95 % yield) as a pale yellow oil. 1H NMR (300 MHz, DMSO-d6) ppm 6.80 – 7.63 (m, 5 H), 4.18 (s, 1 H), 4.00 – 4.16 (m, 2 H), 3.33 – 3.49 (m, 4 H), 2.26 – 2.45 (m, 4 H), 1.95 (s, 3 H), 1.13 (t, 3 H)., 13889-98-0
13889-98-0 1-Acetylpiperazine 83795, apiperazines compound, is more and more widely used in various fields.
Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; PESENTI, Cristina; BOSSOLO, Stefano; WO2013/98145; (2013); A1;,
Piperazine – Wikipedia
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