1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Compound (II) (20.0 g, 35.0 mmol)Dissolved in 300mL of dichloromethane (DCM),Add sequentially at room temperature3-nitro-4-fluorobenzenesulfonamide (8.5 g, 38.5 mmol),4-dimethylaminopyridine (DMAP) (6.4 g, 52.5 mmol),1-Ethyl-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC.HCL) (10.1 g, 52.5 mmol).The reaction was stirred at a temperature of 20 to 30 C for 16 hours.After the reaction was completed, it was washed once by adding 100 mL of a 5% acetic acid aqueous solution.Then wash it again with 100 mL of water.The organic phase is dried with 20 g of sodium sulfate.Filter, spin dry,The fluorine-containing compound (III) solid was 26.1 g, and the yield was 96.3%.Used directly for the next step.
1235865-77-6, The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Chongqing San Sheng Industrial Co., Ltd.; Peng Lei; Huang Xiongjiu; He Wei; Tang Lichang; Liu Ling; Chen Zhenming; (12 pag.)CN109438441; (2019); A;,
Piperazine – Wikipedia
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